ProRule PRU01319

General rule information [?]

Accession PRU01319
Dates 5-MAY-2021 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51975; RNASE_H_2
Name RNase H type-2 domain
Function Ribonuclease H (RNase H) (EC recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes.
Scope(s) Bacteria
Example(s) B8DHN2 (RNH2_LISMH);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=;

Comments [?]

CATALYTIC ACTIVITY Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=;
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
end case

Keywords [?]

Gene Ontology [?]

GO:0003723; Molecular function:RNA binding
case <FTGroup:1>
GO:0004523; Molecular function:RNA-DNA hybrid ribonuclease activity
GO:0006401; Biological process:RNA catabolic process

Features [?]

From: PS51975
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="RNase H type-2"
BINDING 7 7 /ligand="a divalent metal cation"
D 1
BINDING 8 8 /ligand="a divalent metal cation"
E 1
BINDING 105 105 /ligand="a divalent metal cation"
D 1

Additional information [?]

Size range 170-235 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]