 |
|
| annotation rule: PRU01319 |
General rule information
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| Accession | PRU01319 |
| Dates | 5-MAY-2021 (Created) 5-MAY-2021 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS51975; RNASE_H_2 |
| Name | RNase H type-2 domain |
| Function | Ribonuclease H (RNase H) (EC 3.1.26.4) recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes. |
Propagated annotation
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Description
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case <FTGroup:1>
| + RecName: EC 3.1.26.4; |
Comments
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| Catalytic activity | Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
| Cofactor | Mn(2+) Mg(2+) Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding |
end case
Gene Ontology
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GO:0003723; Molecular function: RNA binding.
case <FTGroup:1>
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0006401; Biological process: RNA catabolic process.
Keywords
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end case
Features
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| From: PS51975 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | RNase H type-2 | |||||||||
| METAL | 7 | 7 | Divalent metal cation | D | 1 | |||||||
| METAL | 8 | 8 | Divalent metal cation | E | 1 | |||||||
| METAL | 105 | 105 | Divalent metal cation | D | 1 | |||||||
Additional information
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| Size range | 170-235 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | B8DHN2 (RNH2_LISMH) |
| Scope | Bacteria
Archaea
Eukaryota |
| Comments | None |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Archaea [47] Bacteria [739] Eukaryota [11] All [ 797 ]
- Retrieve set of proteins with 3D structure for this domain