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General rule information [?]

Accession PRU01319
Dates 5-MAY-2021 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51975; RNASE_H_2
Name RNase H type-2 domain
Function Ribonuclease H (RNase H) (EC recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes.

Propagated annotation [?]

Description [?]

case <FTGroup:1>
+ RecName: EC;

Comments [?]

Catalytic activity Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=;
Cofactor Mn(2+)
Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding
end case

Gene Ontology [?]

GO:0003723; Molecular function: RNA binding.
case <FTGroup:1>
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.

Keywords [?]

end case

Features [?]

From: PS51975
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       RNase H type-2        
BINDING     7     7       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     D   1
BINDING     8     8       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     E   1
BINDING     105     105       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     D   1

Additional information [?]

Size range 170-235 amino acids
Related rules None
Repeats 1
Topology Undefined
Example B8DHN2 (RNH2_LISMH)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]