General rule information
[?]
Accession |
PRU01319 |
Dates |
5-MAY-2021 (Created) 14-MAY-2022 (Last updated, Version 3) |
Predictors |
PROSITE; PS51975; RNASE_H_2
|
Name |
RNase H type-2 domain |
Function |
Ribonuclease H (RNase H) (EC 3.1.26.4) recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes. |
Propagated annotation
[?]
case <FTGroup:1>
Catalytic activity |
Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
Cofactor |
Mn(2+) Mg(2+) Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding |
end case
case <FTGroup:1>
GO:0004523; Molecular function: RNA-DNA hybrid ribonuclease activity.
GO:0006401; Biological process: RNA catabolic process.
end case
From: PS51975 |
Key
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From
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To
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Description
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Tag
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|
Condition
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FTGroup
|
DOMAIN
|
|
from
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|
to
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RNase H type-2
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|
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BINDING
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7
|
|
7
|
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/ligand="a divalent metal cation" /ligand_id="60240
|
|
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D
|
|
1
|
BINDING
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|
8
|
|
8
|
|
/ligand="a divalent metal cation" /ligand_id="60240
|
|
|
|
E
|
|
1
|
BINDING
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|
105
|
|
105
|
|
/ligand="a divalent metal cation" /ligand_id="60240
|
|
|
|
D
|
|
1
|
Additional information
[?]
Size range |
170-235 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
B8DHN2 (RNH2_LISMH) |
Scope |
Bacteria
Archaea
Eukaryota |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]