We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01325
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01325
General rule information
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| Accession | PRU01325 |
| Dates | 22-JUL-2021 (Created)
19-NOV-2022 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51981; ZF_RZ |
Name | Zinc finger RZ-type |
| Function | The ubiquitylation of LPS on Salmonella that invade the cytosol relies on the RZ-type zinc finger in the E3 module of RNF213. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | Q9P2E3; |
Propagated annotation
[?]
Keywords
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| Zinc-finger | |
| case <Feature:PS51981:24=[CH]> and <Feature:PS51981:28=[CH]> and <Feature:PS51981:44=[CH]> and <Feature:PS51981:47=[CH]> | |
| Ubl conjugation pathway | |
| Metal-binding | |
| Zinc | |
| end case | |
Features
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| From: PS51981 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <Feature:PS51981:24=C> and <Feature:PS51981:28=H> and <Feature:PS51981:44=C> and <Feature:PS51981:47=C> | ||||||||||||
| ZN_FING | from | to | /note="RZ-type #" | |||||||||
| else case <Feature:PS51981:24=[CH]> and <Feature:PS51981:28=[CH]> and <Feature:PS51981:44=[CH]> and <Feature:PS51981:47=[CH]> | ||||||||||||
| ZN_FING | from | to | /note="RZ-type #; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | from | to | /note="RZ-type #; degenerate" | |||||||||
| end case | ||||||||||||
| ACT_SITE | 35 | 35 | /note="Nucleophile" | C | ||||||||
| BINDING | 24 | 24 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 28 | 28 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 44 | 44 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 47 | 47 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
Additional information
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| Size range | 70-75 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [6] All [ 6 ]
- Retrieve set of proteins with 3D structure for this domain