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annotation rule: PRU01333

General rule information [?]

Accession PRU01333
Dates 9-DEC-2021 (Created)
14-MAY-2022 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51989; COV_NSP2_N
Name Coronavirus (CoV) Nsp2 N-terminal domain
Function The Nsp2 N-terminal domain contains ten alpha-helices and fourteen beta-sheets with three zinc fingers (ZnFs), belonging to the C2H2, C4, and C2HC types, respectively. The three zinc fingers are not involved in binding nucleic acids directly but may play other unknown functions. The interaction of Nsp2 and nucleic acid is mainly dependent on a large positively charged region on the electrostatic surface of the Nsp2 N-terminal domain.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Metal-binding
Zinc
end case

Zinc-finger

Features [?]

From: PS51989
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       CoV Nsp2 N-terminal #        
REGION     18     44       C2H2         1
BINDING     18     18       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   1
BINDING     39     39       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   1
BINDING     42     42       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     H   1
BINDING     44     44       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     H   1
REGION     132     153       C4         2
BINDING     132     132       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   2
BINDING     135     135       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   2
BINDING     151     151       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   2
BINDING     153     153       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   2
REGION     176     213       C2HC         3
BINDING     176     176       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     C   3
BINDING     179     179       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     C   3
BINDING     188     188       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     H   3
BINDING     213     213       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     C   3

Additional information [?]

Size range 230-290 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6U7 (R1A_CVHOC)
Scope
Viruses; Orthocoronavirinae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]