ProRule PRU01333

Accession	PRU01333
Dates	9-DEC-2021 (Created) 19-NOV-2022 (Last updated, Version 3)
Data class	Domain;
Predictors	PROSITE; PS51989; COV_NSP2_N
Name	Coronavirus (CoV) Nsp2 N-terminal domain
Function	The Nsp2 N-terminal domain contains ten alpha-helices and fourteen beta-sheets with three zinc fingers (ZnFs), belonging to the C2H2, C4, and C2HC types, respectively. The three zinc fingers are not involved in binding nucleic acids directly but may play other unknown functions. The interaction of Nsp2 and nucleic acid is mainly dependent on a large positively charged region on the electrostatic surface of the Nsp2 N-terminal domain.
Scope(s)	Viruses Orthocoronavirinae
Example(s)	P0C6U7 (R1A_CVHOC);

From: PS51989
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="CoV Nsp2 N-terminal #"
REGION	18	44	/note="C2H2"			1
BINDING	18	18	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	39	39	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	42	42	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		H	1
BINDING	44	44	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		H	1
REGION	132	153	/note="C4"			2
BINDING	132	132	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	135	135	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	151	151	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	153	153	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
REGION	176	213	/note="C2HC"			3
BINDING	176	176	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3
BINDING	179	179	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3
BINDING	188	188	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		H	3
BINDING	213	213	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3