General rule information
[?]
Accession |
PRU01333 |
Dates |
9-DEC-2021 (Created) 9-DEC-2021 (Last updated, Version 1) |
Predictors |
PROSITE; PS51989; COV_NSP2_N
|
Name |
Coronavirus (CoV) Nsp2 N-terminal domain |
Function |
The Nsp2 N-terminal domain contains ten alpha-helices and fourteen beta-sheets with three zinc fingers (ZnFs), belonging to the C2H2, C4, and C2HC types, respectively. The three zinc fingers are not involved in binding nucleic acids directly but may play other unknown functions. The interaction of Nsp2 and nucleic acid is mainly dependent on a large positively charged region on the electrostatic surface of the Nsp2 N-terminal domain. |
Propagated annotation
[?]
Similarity |
Belongs to the coronaviruses polyprotein 1ab family. |
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.
end case
From: PS51989 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
CoV Nsp2 N-terminal #
|
|
|
|
|
|
|
REGION
|
|
18
|
|
44
|
|
C2H2
|
|
|
|
|
|
1
|
METAL
|
|
18
|
|
18
|
|
Zinc #1
|
|
|
|
C
|
|
1
|
METAL
|
|
39
|
|
39
|
|
Zinc #1
|
|
|
|
C
|
|
1
|
METAL
|
|
42
|
|
42
|
|
Zinc #1
|
|
|
|
H
|
|
1
|
METAL
|
|
44
|
|
44
|
|
Zinc #1
|
|
|
|
H
|
|
1
|
REGION
|
|
132
|
|
153
|
|
C4
|
|
|
|
|
|
2
|
METAL
|
|
132
|
|
132
|
|
Zinc #2
|
|
|
|
C
|
|
2
|
METAL
|
|
135
|
|
135
|
|
Zinc #2
|
|
|
|
C
|
|
2
|
METAL
|
|
151
|
|
151
|
|
Zinc #2
|
|
|
|
C
|
|
2
|
METAL
|
|
153
|
|
153
|
|
Zinc #2
|
|
|
|
C
|
|
2
|
REGION
|
|
176
|
|
213
|
|
C2HC
|
|
|
|
|
|
3
|
METAL
|
|
176
|
|
176
|
|
Zinc #3
|
|
|
|
C
|
|
3
|
METAL
|
|
179
|
|
179
|
|
Zinc #3
|
|
|
|
C
|
|
3
|
METAL
|
|
188
|
|
188
|
|
Zinc #3
|
|
|
|
H
|
|
3
|
METAL
|
|
213
|
|
213
|
|
Zinc #3
|
|
|
|
C
|
|
3
|
Additional information
[?]
Size range |
230-290 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P0C6U7 (R1A_CVHOC) |
Scope |
Viruses; Orthocoronavirinae |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]