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annotation rule: PRU01335 |
General rule information
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Accession |
PRU01335 |
Dates |
9-DEC-2021 (Created) 9-DEC-2021 (Last updated, Version 1) |
Predictors |
PROSITE; PS51991; COV_NSP2_C
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Name |
Coronavirus (CoV) Nsp2 C-terminal domain |
Function |
Nsp2 has been implicated in processes ranging from translation repression to endosomal transport, ribosome biogenesis, and actin filament binding. Nsp2 in SARS-CoV-2 and other coronaviruses have been observed to localize to endosomes and replication-transcription complexes (RTC). Nsp2 may be involved in binding nucleic acids and regulating intracellular signaling pathways. It contains an N-terminal, a middle and a C-terminal domain. |
Propagated annotation
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Similarity |
Belongs to the coronaviruses polyprotein 1ab family. |
From: PS51991 |
Key
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Description
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Tag
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Condition
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FTGroup
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DOMAIN
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from
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to
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CoV Nsp2 C-terminal #
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Additional information
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Size range |
100-140 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P0C6W4 (R1AB_BCHK5) |
Scope |
Viruses; Orthocoronavirinae |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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