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| annotation rule: PRU01335 |
General rule information
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| Accession | PRU01335 |
| Dates | 9-DEC-2021 (Created) 9-DEC-2021 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS51991; COV_NSP2_C |
| Name | Coronavirus (CoV) Nsp2 C-terminal domain |
| Function | Nsp2 has been implicated in processes ranging from translation repression to endosomal transport, ribosome biogenesis, and actin filament binding. Nsp2 in SARS-CoV-2 and other coronaviruses have been observed to localize to endosomes and replication-transcription complexes (RTC). Nsp2 may be involved in binding nucleic acids and regulating intracellular signaling pathways. It contains an N-terminal, a middle and a C-terminal domain. |
Propagated annotation
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Comments
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| Similarity | Belongs to the coronaviruses polyprotein 1ab family. |
Features
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| From: PS51991 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | CoV Nsp2 C-terminal # | |||||||||
Additional information
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| Size range | 100-140 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P0C6W4 (R1AB_BCHK5) |
| Scope | Viruses; Orthocoronavirinae |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Viruses [53]
- Retrieve set of proteins with 3D structure for this domain