Due to maintenance work, this service will be unavailable from
Mon Nov 11 17:30 until
Tue Nov 12 09:00
CET.
Apologies for the inconvenience.
ProRule PRU01335
General rule information
[?]
Accession | PRU01335 |
Dates | 9-DEC-2021 (Created)
-- (Last updated, Version 1) |
Data class | Domain; |
Predictors |
PROSITE; PS51991; COV_NSP2_C |
Name | Coronavirus (CoV) Nsp2 C-terminal domain |
Function | Nsp2 has been implicated in processes ranging from translation repression to endosomal transport, ribosome biogenesis, and actin filament binding. Nsp2 in SARS-CoV-2 and other coronaviruses have been observed to localize to endosomes and replication-transcription complexes (RTC). Nsp2 may be involved in binding nucleic acids and regulating intracellular signaling pathways. It contains an N-terminal, a middle and a C-terminal domain. |
Scope(s) |
Viruses Orthocoronavirinae |
Example(s) | P0C6W4 (R1AB_BCHK5); |
Propagated annotation
[?]
Comments
[?]
SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Features
[?]
From: PS51991 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="CoV Nsp2 C-terminal #" |
Additional information
[?]
Size range | 100-140 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Viruses [53] All [ 53 ]
- Retrieve set of proteins with 3D structure for this domain