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annotation rule: PRU01336

General rule information [?]

Accession PRU01336
Dates 7-JAN-2022 (Created)
7-JAN-2022 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51992; COV_NSP3_Y3
Name Coronavirus Nsp3 Y3 domain
Function The Y1 domain is conserved in all viruses of the order Nidovirales, while Y2 and Y3 are only conserved in all coronaviruses. The three domains from the Y region (Y1 to Y3) are located at the cytosolic side of the ER. The level of their conservation is close to that for the enzymatic domains of Nsp3 and exceeds nonenzymatic ones. From the consistently high conservation of Y1, Y2, and Y3, it has been hypothesize that Y1 to Y3 may form a single functional unit with a conserved enzymatic function. The CoV Nsp3 Y3 domain possesses a well-ordered globular alpha/beta fold.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Features [?]

From: PS51992
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       CoV Nsp3 Y3 #        

Additional information [?]

Size range 100-110 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6V0 (R1A_CVMA5)
Scope
Viruses; Orthocoronavirinae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]