ProRule PRU01336

Accession	PRU01336
Dates	7-JAN-2022 (Created) 6-APR-2023 (Last updated, Version 2)
Data class	Domain;
Predictors	PROSITE; PS51992; COV_NSP3_Y
Name	Coronavirus (CoV) Nsp3 Y domain
Function	The Y domains including Y1 and CoV-Y may form higher-order oligomeric complexes and play a role in pore formation in double-membrane vesicles (DMVs) that serve as the central hubs for viral RNA replication. Specific membrane binding might be a conserved activity of the Y domain.
Scope(s)	Viruses Orthocoronavirinae
Example(s)	P0DTD1 (R1AB_SARS2);

From: PS51992
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="CoV Nsp3 Y #"
REGION	92	to	/note="CoV-Y #"
REGION	from	91	/note="Y1 #"
REGION	92	186	/note="Y2 #"
REGION	187	268	/note="Y3 #"
REGION	269	to	/note="Y4 #"
REGION	5	18	/note="ZF1 #"			1
BINDING	5	5	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		H	1
BINDING	10	10	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	15	15	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	18	18	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
REGION	51	61	/note="ZF2 #"			2
BINDING	51	51	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	54	54	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		H	2
BINDING	58	58	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	61	61	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2