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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01336


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01336
General rule information [?]

Accession PRU01336
Dates 07-JAN-2022 (Created)
06-APR-2023 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51992; COV_NSP3_Y
Name Coronavirus (CoV) Nsp3 Y domain
Function The Y domains including Y1 and CoV-Y may form higher-order oligomeric complexes and play a role in pore formation in double-membrane vesicles (DMVs) that serve as the central hubs for viral RNA replication. Specific membrane binding might be a conserved activity of the Y domain.
Scope(s) Viruses
Orthocoronavirinae
Example(s) P0DTD1;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Keywords [?]

Metal-binding
Zinc
Zinc-finger

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51992
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CoV Nsp3 Y #"
REGION 92 to /note="CoV-Y #"
REGION from 91 /note="Y1 #"
REGION 92 186 /note="Y2 #"
REGION 187 268 /note="Y3 #"
REGION 269 to /note="Y4 #"
REGION 5 18 /note="ZF1 #" 1
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 H 1
BINDING 10 10 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 15 15 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 18 18 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
REGION 51 61 /note="ZF2 #" 2
BINDING 51 51 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 C 2
BINDING 54 54 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 2
BINDING 58 58 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 C 2
BINDING 61 61 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 C 2

Additional information [?]

Size range 340-374 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]