ProRule PRU01337
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01337 |
| Accession | PRU01337 |
| Dates | 30-MAR-2023 (Created)
31-MAR-2023 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51993; COV_3ECTO |
Name | Coronavirus 3Ecto domain |
| Function | The CoV 3Ecto domain is glycosylated and predicted to be located on the lumenal side of the membrane. It has been shown that interaction of the 3Ecto domain with the large lumenal loop of Nsp4 is essential for the endoplasmic reticulum (ER) rearrangements and double-membrane vesicles (DMVs) formation occurring in cells infected by SARS-CoV or mouse hepatitis virus (MHV). |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P0DTD1 (R1AB_SARS2); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Keywords
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| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Features
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| From: PS51993 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="3Ecto #" | |||||||||
| DISULFID | 17 | 44 | disulf | C-x*-C | ||||||||
| DISULFID | 35 | 41 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 75-89 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [59] All [ 59 ]
- Retrieve set of proteins with 3D structure for this domain