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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01337


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01337
General rule information [?]

Accession PRU01337
Dates 28-MAR-2023 (Created)
31-MAR-2023 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51993; COV_3ECTO
Name Coronavirus 3Ecto domain
Function The CoV 3Ecto domain is glycosylated and predicted to be located on the lumenal side of the membrane. It has been shown that interaction of the 3Ecto domain with the large lumenal loop of Nsp4 is essential for the endoplasmic reticulum (ER) rearrangements and double-membrane vesicles (DMVs) formation occurring in cells infected by SARS-CoV or mouse hepatitis virus (MHV).
Scope(s) Viruses
Orthocoronavirinae
Example(s) P0DTD1;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Features [?]

From: PS51993
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="3Ecto #"
DISULFID 17 44 disulf C-x*-C
DISULFID 35 41 disulf C-x*-C

Additional information [?]

Size range 75-89 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]