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General rule information [?]

Accession PRU01337
Dates 30-MAR-2023 (Created)
31-MAR-2023 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51993; COV_3ECTO
Name Coronavirus 3Ecto domain
Function The CoV 3Ecto domain is glycosylated and predicted to be located on the lumenal side of the membrane. It has been shown that interaction of the 3Ecto domain with the large lumenal loop of Nsp4 is essential for the endoplasmic reticulum (ER) rearrangements and double-membrane vesicles (DMVs) formation occurring in cells infected by SARS-CoV or mouse hepatitis virus (MHV).

Propagated annotation [?]

Comments [?]

Similarity Belongs to the coronaviruses polyprotein 1ab family.

Keywords [?]

case <FTTag:disulf>
end case

Features [?]

From: PS51993
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       3Ecto #        
DISULFID     17     44           disulf   C-x*-C  
DISULFID     35     41           disulf   C-x*-C  

Additional information [?]

Size range 75-89 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0DTD1 (R1AB_SARS2)
Viruses; Orthocoronavirinae
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Viruses [59]