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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01340


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01340
General rule information [?]

Accession PRU01340
Dates 04-APR-2022 (Created)
02-MAY-2022 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51996; TR_MART
Name Toxin-related mono-ADP-ribosyltransferase (TR mART) core domain
Function Most known mARTs transfer ADP-ribose onto arginine residues. Some enzymatically inactive mART domains, for example, the N-terminal domains of C2 and VIP2 toxins, have acquired a new, protein-binding function.
Scope(s) Eukaryota
Euteleostomi
Bacteria
Viruses
Example(s) P21454;

Propagated annotation [?]

Keywords [?]

Transferase
NAD
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0106274; Molecular function:NAD+-protein-arginine ADP-ribosyltransferase activity

Cross-references [?]

PROSITE PS01291; ART; 0-1;

Features [?]

From: PS51996
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="TR mART core #"
ACT_SITE 89 89 R 1
ACT_SITE 116 116 S 1
ACT_SITE 157 157 E 1

Additional information [?]

Size range 170-260 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]