PRU01341

General rule information [?]

Accession	PRU01341
Dates	13-APR-2022 (Created) 19-NOV-2022 (Last updated, Version 3)

Data class

Domain

Predictors

PROSITE; PS51997; UPF1_CH_RICH

Name	UPF1 cysteine-histidine-rich (CH-rich) domain

Function

In its N-terminal region, Upf1 has a conserved cysteine-histidine- rich (CH-rich) domain, while centrally it possesses the seven conserved motifs characteristic of eukaryotic group I RNA helicases. The Upf1 CH-rich domain has a cis-inhibitory effect on the ATPase activity and is also the region that binds Upf2.

Propagated annotation [?]

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>

GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Metal-binding
Zinc
Zinc-finger

end case

Features [?]

From: PS51997

Key From To Description Tag Condition FTGroup

DOMAIN from to Upf1 CH-rich #

REGION 9 41 C3H 1

BINDING 9 9 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 C 1

BINDING 12 12 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 C 1

BINDING 31 31 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 C 1

BINDING 41 41 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 H 1

REGION 23 51 CC/SHH/C 2

BINDING 23 23 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 C 2

BINDING 26 26 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 [CS] 2

BINDING 45 45 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 H 2

BINDING 51 51 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 [HC] 2

REGION 69 99 C4 3

BINDING 69 69 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3 C 3

BINDING 72 72 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3 C 3

BINDING 95 95 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3 C 3

BINDING 99 99 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3 C 3

Additional information [?]

Size range	150-340 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q09820 (RENT1_SCHPO)
Scope	Eukaryota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [11]
Retrieve set of proteins with 3D structure for this domain