ProRule PRU01341

Accession	PRU01341
Dates	13-APR-2022 (Created) 19-NOV-2022 (Last updated, Version 3)
Data class	Domain;
Predictors	PROSITE; PS51997; UPF1_CH_RICH
Name	UPF1 cysteine-histidine-rich (CH-rich) domain
Function	In its N-terminal region, Upf1 has a conserved cysteine-histidine- rich (CH-rich) domain, while centrally it possesses the seven conserved motifs characteristic of eukaryotic group I RNA helicases. The Upf1 CH-rich domain has a cis-inhibitory effect on the ATPase activity and is also the region that binds Upf2.
Scope(s)	Eukaryota
Example(s)	Q09820 (RENT1_SCHPO);

From: PS51997
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="Upf1 CH-rich #"
REGION	9	41	/note="C3H"			1
BINDING	9	9	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	12	12	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	31	31	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		C	1
BINDING	41	41	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		H	1
REGION	23	51	/note="CC/SHH/C"			2
BINDING	23	23	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		C	2
BINDING	26	26	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CS]	2
BINDING	45	45	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		H	2
BINDING	51	51	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[HC]	2
REGION	69	99	/note="C4"			3
BINDING	69	69	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3
BINDING	72	72	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3
BINDING	95	95	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3
BINDING	99	99	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#3"		C	3