PROSITE

Accession	PRU01341
Dates	13-APR-2022 (Created) 13-APR-2022 (Last updated, Version 1)

Data class

Domain

Predictors

PROSITE; PS51997; UPF1_CH_RICH

Name	UPF1 cysteine-histidine-rich (CH-rich) domain

Function

In its N-terminal region, Upf1 has a conserved cysteine-histidine- rich (CH-rich) domain, while centrally it possesses the seven conserved motifs characteristic of eukaryotic group I RNA helicases. The Upf1 CH-rich domain has a cis-inhibitory effect on the ATPase activity and is also the region that binds Upf2.

GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.

Metal-binding
Zinc
Zinc-finger

From: PS51997
Key		From		To		Description		Tag		Condition		FTGroup
DOMAIN		from		to		Upf1 CH-rich #
REGION		9		41		C3H						1
METAL		9		9		Zinc #1				C		1
METAL		12		12		Zinc #1				C		1
METAL		31		31		Zinc #1				C		1
METAL		41		41		Zinc #1				H		1
REGION		23		51		CC/SHH/C						2
METAL		23		23		Zinc #2				C		2
METAL		26		26		Zinc #2				[CS]		2
METAL		45		45		Zinc #2				H		2
METAL		51		51		Zinc #2				[HC]		2
REGION		69		99		C4						3
METAL		69		69		Zinc #3				C		3
METAL		72		72		Zinc #3				C		3
METAL		95		95		Zinc #3				C		3
METAL		99		99		Zinc #3				C		3

Size range	150-340 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q09820 (RENT1_SCHPO)
Scope	Eukaryota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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