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annotation rule: PRU01341

General rule information [?]

Accession PRU01341
Dates 13-APR-2022 (Created)
14-MAY-2022 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51997; UPF1_CH_RICH
Name UPF1 cysteine-histidine-rich (CH-rich) domain
Function In its N-terminal region, Upf1 has a conserved cysteine-histidine- rich (CH-rich) domain, while centrally it possesses the seven conserved motifs characteristic of eukaryotic group I RNA helicases. The Upf1 CH-rich domain has a cis-inhibitory effect on the ATPase activity and is also the region that binds Upf2.

Propagated annotation [?]


Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

end case


Features [?]

From: PS51997
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Upf1 CH-rich #        
REGION     9     41       C3H         1
BINDING     9     9       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   1
BINDING     12     12       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   1
BINDING     31     31       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     C   1
BINDING     41     41       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     H   1
REGION     23     51       CC/SHH/C         2
BINDING     23     23       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     C   2
BINDING     26     26       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     [CS]   2
BINDING     45     45       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     H   2
BINDING     51     51       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     [HC]   2
REGION     69     99       C4         3
BINDING     69     69       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     C   3
BINDING     72     72       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     C   3
BINDING     95     95       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     C   3
BINDING     99     99       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     C   3

Additional information [?]

Size range 150-340 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q09820 (RENT1_SCHPO)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]