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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01348


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01348
General rule information [?]

Accession PRU01348
Dates 11-AUG-2022 (Created)
28-FEB-2023 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS52004; KS3_2
Name Ketosynthase family 3 (KS3) domain
Function Ketoacyl synthases (KSs) (more officially 3-oxoacyl synthases and also known as beta-ketoacyl synthases) are the condensing enzymes that catalyze the reaction of acyl-coenzyme A (acyl-CoA) or acyl-acyl carrier protein (acyl-ACP) with malonyl-CoA, malonyl-ACP, or occasionally other substrates.
Scope(s) Eukaryota
Bacteria
Example(s) P9WQE4;

Propagated annotation [?]

Keywords [?]

Transferase
end case

Cross-references [?]

PROSITE PS00606; KS3_1; 1;

Features [?]

From: PS52004
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Ketosynthase family 3 (KS3) #"
ACT_SITE 171 171 /note="For beta-ketoacyl synthase #1 activity" C 1
ACT_SITE 307 307 /note="For beta-ketoacyl synthase #1 activity" H 1
ACT_SITE 347 347 /note="For beta-ketoacyl synthase #1 activity" [HN] 1

Additional information [?]

Size range 240-550 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]