ProRule PRU01348
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01348 |
| Accession | PRU01348 |
| Dates | 11-AUG-2022 (Created)
28-FEB-2023 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52004; KS3_2 |
Name | Ketosynthase family 3 (KS3) domain |
| Function | Ketoacyl synthases (KSs) (more officially 3-oxoacyl synthases and also known as beta-ketoacyl synthases) are the condensing enzymes that catalyze the reaction of acyl-coenzyme A (acyl-CoA) or acyl-acyl carrier protein (acyl-ACP) with malonyl-CoA, malonyl-ACP, or occasionally other substrates. |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | P9WQE4 (PPSB_MYCTO); |
Propagated annotation
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Keywords
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| Transferase | |
| end case | |
Cross-references
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| PROSITE | PS00606; KS3_1; 1; |
Features
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| From: PS52004 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Ketosynthase family 3 (KS3) #" | |||||||||
| ACT_SITE | 171 | 171 | /note="For beta-ketoacyl synthase #1 activity" | C | 1 | |||||||
| ACT_SITE | 307 | 307 | /note="For beta-ketoacyl synthase #1 activity" | H | 1 | |||||||
| ACT_SITE | 347 | 347 | /note="For beta-ketoacyl synthase #1 activity" | [HN] | 1 | |||||||
Additional information
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| Size range | 240-550 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [112] Eukaryota [421] All [ 533 ]
- Retrieve set of proteins with 3D structure for this domain