ProRule PRU01357

Accession	PRU01357
Dates	15-DEC-2022 (Created) -- (Last updated, Version 1)
Data class	Domain;
Predictors	PROSITE; PS52013; ZF_C6H2
Name	Zinc finger C6H2-type
Function	The C6H2-type zinc finger is essential for the normal processing function of MetAP1 and may be important for the proper functional alignment of MetAP1 on the ribosomes. It is a protein-protein interaction domain.
Scope(s)	Eukaryota
Example(s)	Q5RBF3 (MAP1_PONAB);

From: PS52013
Key	From	To	Description	Tag	Condition	FTGroup
case (<Feature:PS52013:4=[C]> and <Feature:PS52013:9=[C]> and <Feature:PS52013:33=[C]> and <Feature:PS52013:37=[C]>) and (<Feature:PS52013:19=[C]> and <Feature:PS52013:22=[C]> and <Feature:PS52013:45=[H]> and <Feature:PS52013:49=[H]>)
ZN_FING	from	to	/note="C6H2-type #"
else case (<Feature:PS52013:4=[CH]> and <Feature:PS52013:9=[CH]> and <Feature:PS52013:33=[CH]> and <Feature:PS52013:37=[CH]>) and (<Feature:PS52013:19=[CH]> and <Feature:PS52013:22=[CH]> and <Feature:PS52013:45=[CH]> and <Feature:PS52013:49=[CH]>)
ZN_FING	from	to	/note="C6H2-type #; atypical"
else
ZN_FING	from	to	/note="C6H2-type #; degenerate"
end case
BINDING	4	4	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	9	9	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	19	19	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2
BINDING	22	22	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2
BINDING	33	33	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	37	37	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	45	45	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2
BINDING	49	49	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2