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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01357


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01357
General rule information [?]

Accession PRU01357
Dates 15-DEC-2022 (Created)
15-DEC-2022 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52013; ZF_C6H2
Name Zinc finger C6H2-type
Function The C6H2-type zinc finger is essential for the normal processing function of MetAP1 and may be important for the proper functional alignment of MetAP1 on the ribosomes. It is a protein-protein interaction domain.
Scope(s) Eukaryota
Example(s) Q5RBF3;

Propagated annotation [?]

Comments [?]

case (<Feature:PS52013:4=[CH]> and <Feature:PS52013:9=[CH]> and <Feature:PS52013:33=[CH]> and <Feature:PS52013:37=[CH]>) or (<Feature:PS52013:19=[CH]> and <Feature:PS52013:22=[CH]> and <Feature:PS52013:45=[CH]> and <Feature:PS52013:49=[CH]>)
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case
SIMILARITYBelongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.

Keywords [?]

Zinc
Metal-binding
end case
Zinc-finger

Gene Ontology [?]

case (<Feature:PS52013:4=[CH]> and <Feature:PS52013:9=[CH]> and <Feature:PS52013:33=[CH]> and <Feature:PS52013:37=[CH]>) or (<Feature:PS52013:19=[CH]> and <Feature:PS52013:22=[CH]> and <Feature:PS52013:45=[CH]> and <Feature:PS52013:49=[CH]>)
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS52013
Key From To Description Tag Condition FTGroup
case (<Feature:PS52013:4=[C]> and <Feature:PS52013:9=[C]> and <Feature:PS52013:33=[C]> and <Feature:PS52013:37=[C]>) and (<Feature:PS52013:19=[C]> and <Feature:PS52013:22=[C]> and <Feature:PS52013:45=[H]> and <Feature:PS52013:49=[H]>)
ZN_FING from to /note="C6H2-type #"
else case (<Feature:PS52013:4=[CH]> and <Feature:PS52013:9=[CH]> and <Feature:PS52013:33=[CH]> and <Feature:PS52013:37=[CH]>) and (<Feature:PS52013:19=[CH]> and <Feature:PS52013:22=[CH]> and <Feature:PS52013:45=[CH]> and <Feature:PS52013:49=[CH]>)
ZN_FING from to /note="C6H2-type #; atypical"
else
ZN_FING from to /note="C6H2-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 19 19 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 22 22 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 33 33 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 37 37 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 45 45 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 49 49 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2

Additional information [?]

Size range 53-59 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]