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ProRule PRU01357


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PURL: https://purl.expasy.org/prosite/rule/PRU01357
General rule information [?]

Accession PRU01357
Dates 15-DEC-2022 (Created)
15-DEC-2022 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52013; ZF_C6H2
Name Zinc finger C6H2-type
Function The C6H2-type zinc finger is essential for the normal processing function of MetAP1 and may be important for the proper functional alignment of MetAP1 on the ribosomes. It is a protein-protein interaction domain.
Scope(s) Eukaryota
Example(s) Q5RBF3;

Propagated annotation [?]

Comments [?]

case (<Feature:PS52013:4=[CH]> and <Feature:PS52013:9=[CH]> and <Feature:PS52013:33=[CH]> and <Feature:PS52013:37=[CH]>) or (<Feature:PS52013:19=[CH]> and <Feature:PS52013:22=[CH]> and <Feature:PS52013:45=[CH]> and <Feature:PS52013:49=[CH]>)
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case
SIMILARITYBelongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.

Keywords [?]

Zinc
Metal-binding
end case
Zinc-finger

Gene Ontology [?]

case (<Feature:PS52013:4=[CH]> and <Feature:PS52013:9=[CH]> and <Feature:PS52013:33=[CH]> and <Feature:PS52013:37=[CH]>) or (<Feature:PS52013:19=[CH]> and <Feature:PS52013:22=[CH]> and <Feature:PS52013:45=[CH]> and <Feature:PS52013:49=[CH]>)
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS52013
Key From To Description Tag Condition FTGroup
case (<Feature:PS52013:4=[C]> and <Feature:PS52013:9=[C]> and <Feature:PS52013:33=[C]> and <Feature:PS52013:37=[C]>) and (<Feature:PS52013:19=[C]> and <Feature:PS52013:22=[C]> and <Feature:PS52013:45=[H]> and <Feature:PS52013:49=[H]>)
ZN_FING from to /note="C6H2-type #"
else case (<Feature:PS52013:4=[CH]> and <Feature:PS52013:9=[CH]> and <Feature:PS52013:33=[CH]> and <Feature:PS52013:37=[CH]>) and (<Feature:PS52013:19=[CH]> and <Feature:PS52013:22=[CH]> and <Feature:PS52013:45=[CH]> and <Feature:PS52013:49=[CH]>)
ZN_FING from to /note="C6H2-type #; atypical"
else
ZN_FING from to /note="C6H2-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 19 19 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 22 22 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 33 33 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 37 37 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 45 45 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 49 49 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2

Additional information [?]

Size range 53-59 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]