We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01359
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01359
General rule information
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| Accession | PRU01359 |
| Dates | 27-JAN-2023 (Created)
27-JAN-2023 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52015; TONB_CTD |
Name | TonB C-terminal domain |
| Function | The TonB protein plays an essential role in the energy transduction system to drive active transport across the outer membrane (OM) using the proton-motive force of the cytoplasmic membrane of Gram-negative bacteria. The C-terminal domain (CTD) of TonB protein is known to interact with the conserved TonB box motif of TonB-dependent OM transporters, which likely induces structural changes in the OM transporters. |
| Scope(s) |
Bacteria Pseudomonadota |
| Example(s) | O52042; |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein; Periplasmic side. |
| SIMILARITY | Belongs to the TonB family. |
Keywords
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| Cell inner membrane |
| Cell membrane |
| Membrane |
| Protein transport |
| Transmembrane |
| Transmembrane helix |
| Transport |
Gene Ontology
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| GO:0055085; Biological process:transmembrane transport |
| GO:0015031; Biological process:protein transport |
| GO:0031992; Molecular function:energy transducer activity |
| GO:0030288; Cellular component:outer membrane-bounded periplasmic space |
Features
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| From: PS52015 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="TonB C-terminal #" | |||||||||
Additional information
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| Size range | 85-95 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [22] All [ 22 ]
- Retrieve set of proteins with 3D structure for this domain