PRU01362
General rule information
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Accession | PRU01362 |
Dates | 21-FEB-2023 (Created) 21-FEB-2023 (Last updated, Version 1) |
Data class | Domain |
Predictors | PROSITE; PS52018; DART |
Name | DNA ADP-ribosyl transferase (DarT) domain |
Function | The bacterial DNA ADP-ribosyl transferase (DarT) protein is a toxin that has been shown to transfer ADP-ribose from NAD(+) onto thymidine bases present in single-stranded DNA (ssDNA) specifically at the four-base motif TNTC, and to have no activity on RNA or protein targets. |
Propagated annotation
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Comments
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case <FTGroup:1>
Catalytic activity | RHEA:71651: a thymidine in DNA + NAD(+) = an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide
PhysiologicalDirection=left-to-right (RHEA:71652) |
end case
Similarity | Belongs to the DarT ADP-ribosyltransferase family. |
Gene Ontology
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GO:0003677; Molecular function: DNA binding.
case <FTGroup:1>
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0016757; Molecular function: glycosyltransferase activity.
GO:0016757; Molecular function: glycosyltransferase activity.
Keywords
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end case
Features
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From: PS52018 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | DarT | |||||||||
BINDING | 5 | 7 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | 1 |
case <FTGroup:1>
BINDING | 14 | 14 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | G | ||||||||
BINDING | 22 | 22 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | L |
end case
ACT_SITE | 44 | 44 | Proton acceptor | R | 1 | |||||||
BINDING | 44 | 44 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | 1 | ||||||||
ACT_SITE | 141 | 141 | E | 1 |
Additional information
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Size range | 192-205 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | A0A0B0SG80 (DART_THES0) |
Scope | Bacteria |
Comments | None |
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