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General rule information [?]

Accession PRU01362
Dates 21-FEB-2023 (Created)
21-FEB-2023 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS52018; DART
Name DNA ADP-ribosyl transferase (DarT) domain
Function The bacterial DNA ADP-ribosyl transferase (DarT) protein is a toxin that has been shown to transfer ADP-ribose from NAD(+) onto thymidine bases present in single-stranded DNA (ssDNA) specifically at the four-base motif TNTC, and to have no activity on RNA or protein targets.

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
Catalytic activity RHEA:71651: a thymidine in DNA + NAD(+) = an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H(+) + nicotinamide
PhysiologicalDirection=left-to-right (RHEA:71652)
end case

Similarity Belongs to the DarT ADP-ribosyltransferase family.

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
case <FTGroup:1>
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0016757; Molecular function: glycosyltransferase activity.

Keywords [?]

end case

Features [?]

From: PS52018
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       DarT        
BINDING     5     7       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540         1
case <FTGroup:1>
BINDING     14     14       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     G  
BINDING     22     22       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     L  
end case

ACT_SITE     44     44       Proton acceptor     R   1
BINDING     44     44       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540         1
ACT_SITE     141     141             E   1

Additional information [?]

Size range 192-205 amino acids
Related rules None
Repeats 1
Topology Undefined
Example A0A0B0SG80 (DART_THES0)
Comments None


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