PRU01369

General rule information [?]

Accession	PRU01369
Dates	9-JUN-2023 (Created) 9-JUN-2023 (Last updated, Version 1)

Data class

Domain

Predictors

PROSITE; PS52025; GL_BHV

Name	Betaherpesvirus glycoprotein L (gL) domain

Function

Two glycoprotein complexes are conserved throughout the three herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL), the role of which is less clearly defined. The intrinsic structural plasticity of gH/gL enables it to function as a signal integration machine that can accept diverse regulatory inputs and convert them into a "trigger" signal that activates the fusogenic ability of gB.

Propagated annotation [?]

Description [?]

+ AltName: Full=Envelope glycoprotein L; Short=gL;

Comments [?]

Subcellular location	Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.
Similarity	Belongs to the herpesviridae glycoprotein L (gL) family. Betaherpesvirinae gL subfamily.

Gene Ontology [?]

GO:0046718; Biological process: viral entry into host cell.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0019031; Cellular component: viral envelope.
GO:0055036; Cellular component: virion membrane.
GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0016020; Cellular component: membrane.

Keywords [?]

Fusion of virus membrane with host cell membrane
Fusion of virus membrane with host membrane
Glycoprotein
Host Golgi apparatus
Host cell membrane
Host membrane
Membrane
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virus entry into host cell

case <FTTag:disulf>

Disulfide bond

end case

Features [?]

From: PS52025

Key From To Description Tag Condition FTGroup

DOMAIN from to gL betaherpesvirus-type #

DISULFID 5 5 Interchain disulf C

DISULFID 12 12 Interchain disulf C

DISULFID 102 102 Interchain disulf C

DISULFID 112 117 disulf C-x*-C

Additional information [?]

Size range	201-214 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	O92277 (GL_GPCMV)
Scope	Viruses; Betaherpesvirinae
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Viruses [17]
Retrieve set of proteins with 3D structure for this domain