PRU01370
General rule information
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| Accession | PRU01370 |
| Dates | 9-JUN-2023 (Created) 9-JUN-2023 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS52026; GL_GHV |
| Name | Gammaherpesvirus glycoprotein L (gL) domain |
| Function | Two glycoprotein complexes are conserved throughout the three herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL), the role of which is less clearly defined. The intrinsic structural plasticity of gH/gL enables it to function as a signal integration machine that can accept diverse regulatory inputs and convert them into a "trigger" signal that activates the fusogenic ability of gB. |
Propagated annotation
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Description
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| + AltName: Full=Envelope glycoprotein L; Short=gL; |
Comments
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| Subcellular location | Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs. {ECO:0000255|HAMAP-Rule:MF_04034}. |
| Similarity | Belongs to the herpesviridae glycoprotein L (gL) family. Gammaherpesvirinae gL subfamily. |
Gene Ontology
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GO:0046718; Biological process: viral entry into host cell.
GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0055036; Cellular component: virion membrane.
GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0055036; Cellular component: virion membrane.
GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.
Keywords
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Fusion of virus membrane with host cell membrane
Fusion of virus membrane with host membrane
Glycoprotein
Host Golgi apparatus
Host cell membrane
Host membrane
Membrane
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virus entry into host cell
Fusion of virus membrane with host membrane
Glycoprotein
Host Golgi apparatus
Host cell membrane
Host membrane
Membrane
Viral envelope protein
Viral penetration into host cytoplasm
Virion
Virus entry into host cell
case <FTTag:disulf>
end case
Features
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| From: PS52026 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | gL gammaherpesvirus-type # | |||||||||
| DISULFID | 3 | 31 | disulf | C-x*-C | ||||||||
| DISULFID | 4 | 52 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 108-118 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P03212 (GL_EBVB9) |
| Scope | Viruses; Gammaherpesvirinae |
| Comments | None |
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