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General rule information [?]

Accession PRU01370
Dates 9-JUN-2023 (Created)
9-JUN-2023 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS52026; GL_GHV
Name Gammaherpesvirus glycoprotein L (gL) domain
Function Two glycoprotein complexes are conserved throughout the three herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL), the role of which is less clearly defined. The intrinsic structural plasticity of gH/gL enables it to function as a signal integration machine that can accept diverse regulatory inputs and convert them into a "trigger" signal that activates the fusogenic ability of gB.

Propagated annotation [?]

Description [?]

+ AltName: Full=Envelope glycoprotein L; Short=gL;

Comments [?]

Subcellular location Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs. {ECO:0000255|HAMAP-Rule:MF_04034}.
Similarity Belongs to the herpesviridae glycoprotein L (gL) family. Gammaherpesvirinae gL subfamily.

Gene Ontology [?]

GO:0046718; Biological process: viral entry into host cell.
GO:0016020; Cellular component: membrane.
GO:0019031; Cellular component: viral envelope.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0055036; Cellular component: virion membrane.
GO:0044177; Cellular component: host cell Golgi apparatus.
GO:0019064; Biological process: fusion of virus membrane with host plasma membrane.

Keywords [?]

case <FTTag:disulf>
end case

Features [?]

From: PS52026
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       gL gammaherpesvirus-type #        
DISULFID     3     31           disulf   C-x*-C  
DISULFID     4     52           disulf   C-x*-C  

Additional information [?]

Size range 108-118 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P03212 (GL_EBVB9)
Viruses; Gammaherpesvirinae
Comments None


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