ProRule PRU01370

General rule information [?]

Accession PRU01370
Dates 9-JUN-2023 (Created)
11-JUL-2023 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52026; GL_GHV
Name Gammaherpesvirus glycoprotein L (gL) domain
Function Two glycoprotein complexes are conserved throughout the three herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL), the role of which is less clearly defined. The intrinsic structural plasticity of gH/gL enables it to function as a signal integration machine that can accept diverse regulatory inputs and convert them into a "trigger" signal that activates the fusogenic ability of gB.
Scope(s) Viruses
Example(s) P03212 (GL_EBVB9);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Envelope glycoprotein L;

Comments [?]

SUBCELLULAR LOCATIONVirion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.
SIMILARITYBelongs to the herpesviridae glycoprotein L (gL) family. Gammaherpesvirinae gL subfamily.

Keywords [?]

Gene Ontology [?]

GO:0046718; Biological process:viral entry into host cell
GO:0016020; Cellular component:membrane
GO:0019031; Cellular component:viral envelope
GO:0020002; Cellular component:host cell plasma membrane
GO:0055036; Cellular component:virion membrane
GO:0044177; Cellular component:host cell Golgi apparatus
GO:0019064; Biological process:fusion of virus membrane with host plasma membrane

Features [?]

From: PS52026
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="gL gammaherpesvirus-type #"
DISULFID 3 31 disulf C-x*-C
DISULFID 4 52 disulf C-x*-C

Additional information [?]

Size range 108-118 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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