ProRule PRU01370
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01370 |
| Accession | PRU01370 |
| Dates | 9-JUN-2023 (Created)
1-MAR-2024 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52026; GL_GHV |
Name | Gammaherpesvirus glycoprotein L (gL) domain |
| Function | Two glycoprotein complexes are conserved throughout the three herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL), the role of which is less clearly defined. The intrinsic structural plasticity of gH/gL enables it to function as a signal integration machine that can accept diverse regulatory inputs and convert them into a "trigger" signal that activates the fusogenic ability of gB. |
| Scope(s) |
Viruses Gammaherpesvirinae |
| Example(s) | P03212 (GL_EBVB9); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Envelope glycoprotein L; Short=gL; |
Comments
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| SUBCELLULAR LOCATION | Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs. |
| SIMILARITY | Belongs to the herpesviridae glycoprotein L (gL) family. Gammaherpesvirinae gL subfamily. |
Keywords
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Gene Ontology
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| GO:0046718; Biological process:symbiont entry into host cell |
| GO:0016020; Cellular component:membrane |
| GO:0019031; Cellular component:viral envelope |
| GO:0020002; Cellular component:host cell plasma membrane |
| GO:0055036; Cellular component:virion membrane |
| GO:0044177; Cellular component:host cell Golgi apparatus |
| GO:0019064; Biological process:fusion of virus membrane with host plasma membrane |
Features
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| From: PS52026 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="gL gammaherpesvirus-type #" | |||||||||
| DISULFID | 3 | 31 | disulf | C-x*-C | ||||||||
| DISULFID | 4 | 52 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 108-118 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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