ProRule PRU01370
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01370
General rule information
[?]
| Accession | PRU01370 |
| Dates | 09-JUN-2023 (Created)
01-MAR-2024 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52026; GL_GHV |
Name | Gammaherpesvirus glycoprotein L (gL) domain |
| Function | Two glycoprotein complexes are conserved throughout the three herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL), the role of which is less clearly defined. The intrinsic structural plasticity of gH/gL enables it to function as a signal integration machine that can accept diverse regulatory inputs and convert them into a "trigger" signal that activates the fusogenic ability of gB. |
| Scope(s) |
Viruses Gammaherpesvirinae |
| Example(s) | P03212 (GL_EBVB9); |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Protein name | + AltName: Full=Envelope glycoprotein L; Short=gL; |
Comments
[?]
| SUBCELLULAR LOCATION | Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs. |
| SIMILARITY | Belongs to the herpesviridae glycoprotein L (gL) family. Gammaherpesvirinae gL subfamily. |
Keywords
[?]
Gene Ontology
[?]
| GO:0046718; Biological process:symbiont entry into host cell |
| GO:0016020; Cellular component:membrane |
| GO:0019031; Cellular component:viral envelope |
| GO:0020002; Cellular component:host cell plasma membrane |
| GO:0055036; Cellular component:virion membrane |
| GO:0044177; Cellular component:host cell Golgi apparatus |
| GO:0019064; Biological process:fusion of virus membrane with host plasma membrane |
Features
[?]
| From: PS52026 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="gL gammaherpesvirus-type #" | |||||||||
| DISULFID | 3 | 31 | disulf | C-x*-C | ||||||||
| DISULFID | 4 | 52 | disulf | C-x*-C | ||||||||
Additional information
[?]
| Size range | 108-118 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.