We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01370
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01370
General rule information
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| Accession | PRU01370 |
| Dates | 09-JUN-2023 (Created)
01-MAR-2024 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52026; GL_GHV |
Name | Gammaherpesvirus glycoprotein L (gL) domain |
| Function | Two glycoprotein complexes are conserved throughout the three herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL), the role of which is less clearly defined. The intrinsic structural plasticity of gH/gL enables it to function as a signal integration machine that can accept diverse regulatory inputs and convert them into a "trigger" signal that activates the fusogenic ability of gB. |
| Scope(s) |
Viruses Gammaherpesvirinae |
| Example(s) | P03212; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Envelope glycoprotein L; Short=gL; |
Comments
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| SUBCELLULAR LOCATION | Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network. Note=gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs. |
| SIMILARITY | Belongs to the herpesviridae glycoprotein L (gL) family. Gammaherpesvirinae gL subfamily. |
Keywords
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Gene Ontology
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| GO:0046718; Biological process:symbiont entry into host cell |
| GO:0016020; Cellular component:membrane |
| GO:0019031; Cellular component:viral envelope |
| GO:0020002; Cellular component:host cell plasma membrane |
| GO:0055036; Cellular component:virion membrane |
| GO:0044177; Cellular component:host cell Golgi apparatus |
| GO:0019064; Biological process:fusion of virus membrane with host plasma membrane |
Features
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| From: PS52026 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="gL gammaherpesvirus-type #" | |||||||||
| DISULFID | 3 | 31 | disulf | C-x*-C | ||||||||
| DISULFID | 4 | 52 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 108-118 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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