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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01371


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01371
General rule information [?]

Accession PRU01371
Dates 02-JUN-2023 (Created)
02-JUN-2023 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52027; ZF_C2HC_C3H
Name Zinc finger C2HC/C3H-type
Function The C2HC/C3H-type zinc finger has first been identified in four copies in Zfp474, a protein exclusively found in testis and ovary and thought to function as a germ cell specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
Scope(s) Eukaryota
Example(s) Q6V5K9;

Propagated annotation [?]

Comments [?]

case (<Feature:PS52027:5=[CH]> and <Feature:PS52027:8=[CH]> and <Feature:PS52027:20=[HC]> and <Feature:PS52027:24=[CH]>)
COFACTORName=Zn(2+); Xref=ChEBI:CHEBI:29105;

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

GO:0008270; Molecular function:zinc ion binding
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS52027
Key From To Description Tag Condition FTGroup
case (<Feature:PS52027:5=C> and <Feature:PS52027:8=C> and <Feature:PS52027:20=H> and <Feature:PS52027:24=C>)
ZN_FING from to /note="C2HC/C3H-type #"
else case (<Feature:PS52027:5=[CH]> and <Feature:PS52027:8=[CH]> and <Feature:PS52027:20=[HC]> and <Feature:PS52027:24=[CH]>)
ZN_FING from to /note="C2HC/C3H-type #; atypical"
else
ZN_FING from to /note="C2HC/C3H-type #; degenerate"
end case
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 8 8 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 20 20 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 24 24 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 25-35 amino acids
Related rules None
Fusion None
Repeats 1-6
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]