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General rule information [?]

Accession PRU01371
Dates 2-JUN-2023 (Created)
2-JUN-2023 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS52027; ZF_C2HC_C3H
Name Zinc finger C2HC/C3H-type
Function The C2HC/C3H-type zinc finger has first been identified in four copies in Zfp474, a protein exclusively found in testis and ovary and thought to function as a germ cell specific transcription factor that plays important roles in spermatid differentiation and oocyte development.

Propagated annotation [?]

Comments [?]

case (<Feature:PS52027:5=[CH]> and <Feature:PS52027:8=[CH]> and <Feature:PS52027:20=[HC]> and <Feature:PS52027:24=[CH]>)
Cofactor Zn(2+)

Gene Ontology [?]

GO:0008270; Molecular function: zinc ion binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case

Features [?]

case (<Feature:PS52027:5=C> and <Feature:PS52027:8=C> and <Feature:PS52027:20=H> and <Feature:PS52027:24=C>)
From: PS52027
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     from     to       C2HC/C3H-type #        
else case (<Feature:PS52027:5=[CH]> and <Feature:PS52027:8=[CH]> and <Feature:PS52027:20=[HC]> and <Feature:PS52027:24=[CH]>)
ZN_FING     from     to       C2HC/C3H-type #; atypical        
ZN_FING     from     to       C2HC/C3H-type #; degenerate        
end case

BINDING     5     5       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     8     8       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     20     20       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1
BINDING     24     24       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1     [CH]   1

Additional information [?]

Size range 25-35 amino acids
Related rules None
Repeats 1-6
Topology Undefined
Example Q6V5K9 (ZN474_MOUSE)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Eukaryota [23]