PRU01371

General rule information [?]

Accession	PRU01371
Dates	2-JUN-2023 (Created) 2-JUN-2023 (Last updated, Version 1)

Data class

Domain

Predictors

PROSITE; PS52027; ZF_C2HC_C3H

Name	Zinc finger C2HC/C3H-type

Function

The C2HC/C3H-type zinc finger has first been identified in four copies in Zfp474, a protein exclusively found in testis and ovary and thought to function as a germ cell specific transcription factor that plays important roles in spermatid differentiation and oocyte development.

Propagated annotation [?]

Comments [?]

case (<Feature:PS52027:5=[CH]> and <Feature:PS52027:8=[CH]> and <Feature:PS52027:20=[HC]> and <Feature:PS52027:24=[CH]>)

Cofactor

Zn(2+)

Gene Ontology [?]

GO:0008270; Molecular function: zinc ion binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Metal-binding
Zinc

end case

Zinc-finger

Features [?]

case (<Feature:PS52027:5=C> and <Feature:PS52027:8=C> and <Feature:PS52027:20=H> and <Feature:PS52027:24=C>)

From: PS52027

Key From To Description Tag Condition FTGroup

ZN_FING from to C2HC/C3H-type #

else case (<Feature:PS52027:5=[CH]> and <Feature:PS52027:8=[CH]> and <Feature:PS52027:20=[HC]> and <Feature:PS52027:24=[CH]>)

ZN_FING from to C2HC/C3H-type #; atypical

else

ZN_FING from to C2HC/C3H-type #; degenerate

end case

BINDING 5 5 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 [CH] 1

BINDING 8 8 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 [CH] 1

BINDING 20 20 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 [CH] 1

BINDING 24 24 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 [CH] 1

Additional information [?]

Size range	25-35 amino acids
Related rules	None
Repeats	1-6
Topology	Undefined
Example	Q6V5K9 (ZN474_MOUSE)
Scope	Eukaryota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota

[23]