ProRule PRU01371
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01371 |
| Accession | PRU01371 |
| Dates | 2-JUN-2023 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52027; ZF_C2HC_C3H |
Name | Zinc finger C2HC/C3H-type |
| Function | The C2HC/C3H-type zinc finger has first been identified in four copies in Zfp474, a protein exclusively found in testis and ovary and thought to function as a germ cell specific transcription factor that plays important roles in spermatid differentiation and oocyte development. |
| Scope(s) |
Eukaryota |
| Example(s) | Q6V5K9 (ZN474_MOUSE); |
Propagated annotation
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Comments
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| case (<Feature:PS52027:5=[CH]> and <Feature:PS52027:8=[CH]> and <Feature:PS52027:20=[HC]> and <Feature:PS52027:24=[CH]>) | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; |
Keywords
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| Metal-binding | |
| Zinc | |
| end case | |
| Zinc-finger | |
Gene Ontology
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| GO:0008270; Molecular function:zinc ion binding |
| GO:0046872; Molecular function:metal ion binding |
Features
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| From: PS52027 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case (<Feature:PS52027:5=C> and <Feature:PS52027:8=C> and <Feature:PS52027:20=H> and <Feature:PS52027:24=C>) | ||||||||||||
| ZN_FING | from | to | /note="C2HC/C3H-type #" | |||||||||
| else case (<Feature:PS52027:5=[CH]> and <Feature:PS52027:8=[CH]> and <Feature:PS52027:20=[HC]> and <Feature:PS52027:24=[CH]>) | ||||||||||||
| ZN_FING | from | to | /note="C2HC/C3H-type #; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | from | to | /note="C2HC/C3H-type #; degenerate" | |||||||||
| end case | ||||||||||||
| BINDING | 5 | 5 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 8 | 8 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 20 | 20 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 24 | 24 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
Additional information
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| Size range | 25-35 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-6 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [23] All [ 23 ]
- Retrieve set of proteins with 3D structure for this domain