ProRule PRU01372
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01372 |
| Accession | PRU01372 |
| Dates | 29-JUN-2023 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52028; SMCR |
Name | Streptococcal M proteins C repeat |
| Function | M proteins belong to a family of fibrous streptococcal surface proteins which represent major virulence factors due to their antiphagocytic activities. The C repeats are present in all M proteins, although the number of repeat sequences varies from two (M6) to four (M12). The conserved repetitive C units are responsible for several biological activities of M and M-like proteins. |
| Scope(s) |
Bacteria Streptococcus |
| Example(s) | P16947 (M49_STRP9); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Secreted, cell wall; Peptidoglycan-anchor. |
| SIMILARITY | Belongs to the M protein family. |
Keywords
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Gene Ontology
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| GO:0005576; Cellular component:extracellular region |
Features
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| From: PS52028 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | from | to | /note="C #" | |||||||||
Additional information
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| Size range | 35-36 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 2-4 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [12] All [ 12 ]
- Retrieve set of proteins with 3D structure for this domain