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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01372


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PURL: https://purl.expasy.org/prosite/rule/PRU01372
General rule information [?]

Accession PRU01372
Dates 29-JUN-2023 (Created)
29-JUN-2023 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52028; SMCR
Name Streptococcal M proteins C repeat
Function M proteins belong to a family of fibrous streptococcal surface proteins which represent major virulence factors due to their antiphagocytic activities. The C repeats are present in all M proteins, although the number of repeat sequences varies from two (M6) to four (M12). The conserved repetitive C units are responsible for several biological activities of M and M-like proteins.
Scope(s) Bacteria
Streptococcus
Example(s) P16947;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONSecreted, cell wall; Peptidoglycan-anchor.
SIMILARITYBelongs to the M protein family.

Keywords [?]

Cell wall
Peptidoglycan-anchor
Secreted

Gene Ontology [?]

GO:0005576; Cellular component:extracellular region

Features [?]

From: PS52028
Key From To Description Tag Condition FTGroup
REPEAT from to /note="C #"

Additional information [?]

Size range 35-36 amino acids
Related rules None
Fusion None
Repeats 2-4
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]