ProRule PRU01378
General rule information
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Accession | PRU01378 |
Dates | 4-AUG-2023 (Created)
8-AUG-2023 (Last updated, Version 2) |
Data class | Domain; |
Predictors |
PROSITE; PS52034; PEPTIDASE_M32 |
Name | Peptidase family M32 domain |
Function | The M32 family of Zn-dependent metallocarboxypeptidases (MCPs) contains a group of hydrolases, which although being broadly distributed among prokaryotic organisms, are only present in a few eukaryotes including some green algae and trypanosomatids. |
Scope(s) |
Bacteria Archaea Pyrococcus |
Example(s) | P50848 (CBP1_BACSU); |
Propagated annotation
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Identifier, protein and gene names
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case <FTTag:act_site> and <FTGroup:1> | |
Protein name | + AltName: EC=3.4.17.19; |
end case |
Comments
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case <FTTag:act_site> and <FTGroup:1> | |
CATALYTIC ACTIVITY | Reaction=Release of a C-terminal amino acid with broad specificity, except for -Pro.; EC=3.4.17.19; |
end case | |
case <FTGroup:1> | |
COFACTOR | Name=a divalent metal cation; Xref=CHEBI:60240; Note=Binds 1 divalent metal cation per subunit. |
end case | |
SIMILARITY | Belongs to the peptidase M32 family. |
Keywords
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Carboxypeptidase | |
Hydrolase | |
Metalloprotease | |
Protease | |
end case | |
case <FTGroup:1> | |
Metal-binding | |
end case |
Gene Ontology
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case <FTTag:act_site> and <FTGroup:1> | |
GO:0004181; Molecular function:metallocarboxypeptidase activity | |
GO:0006508; Biological process:proteolysis |
Features
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From: PS52034 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Peptidase M32 #" | |||||||||
MOTIF | 232 | 234 | /note="HPF #" | H-P-F | ||||||||
MOTIF | 241 | 245 | /note="DXRXT #" | D-x-R-x-T | ||||||||
MOTIF | 262 | 266 | /note="HEXXH #" | H-E-x(2)-H | ||||||||
MOTIF | 291 | 294 | /note="HES/GQ #" | H-E-[SG]-Q | ||||||||
MOTIF | 344 | 349 | /note="I/NRXXA/SD #" | [IN]-R-x(2)-[AS]-D | ||||||||
MOTIF | 399 | 406 | /note="GXXQDXHW #" | G-x(2)-Q-D-x-H-W | ||||||||
ACT_SITE | 263 | 263 | /note="Proton donor/acceptor" | act_site | E | |||||||
BINDING | 262 | 262 | /ligand="a divalent metal cation #" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic" |
H | 1 | |||||||
BINDING | 266 | 266 | /ligand="a divalent metal cation #" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic" |
H | 1 | |||||||
BINDING | 292 | 292 | /ligand="a divalent metal cation #" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="catalytic" |
E | 1 |
Additional information
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Size range | 494-504 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [1] Bacteria [3] All [ 4 ]
- Retrieve set of proteins with 3D structure for this domain