ProRule PRU01381

Accession	PRU01381
Dates	13-SEP-2023 (Created) -- (Last updated, Version 1)
Data class	Domain;
Predictors	PROSITE; PS52037; ZF_RG_C
Name	Zinc finger reverse gyrase C-terminal-type
Function	Reverse gyrase (RG) is an ATP-dependent topoisomerase that is only found in archaeal and bacterial hyperthermophiles (above 80 degre C) and thermophiles (65-80 degre C). The RG C-terminal-type zinc finger is inserted into the Toprim domain at the base of the DNA-binding site and protrudes from the surface of the topoisomerase domain.
Scope(s)	Archaea Bacteria
Example(s)	O29238 (RGYR_ARCFU);

From: PS52037
Key	From	To	Description	Tag	Condition	FTGroup
case (<Feature:PS52037:4=[C]> and <Feature:PS52037:7=[C]> and <Feature:PS52037:18=[C]> and <Feature:PS52037:21=[C]>)
ZN_FING	from	to	/note="RG C-terminal-type #"
else case (<Feature:PS52037:4=[CH]> and <Feature:PS52037:7=[CH]> and <Feature:PS52037:18=[CH]> and <Feature:PS52037:21=[CH]>)
ZN_FING	from	to	/note="RG C-terminal-type #; atypical"
else
ZN_FING	from	to	/note="RG C-terminal-type #; degenerate"
end case
BINDING	4	4	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	7	7	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	18	18	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	21	21	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1