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ProRule PRU01381


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PURL: https://purl.expasy.org/prosite/rule/PRU01381
General rule information [?]

Accession PRU01381
Dates 13-SEP-2023 (Created)
13-SEP-2023 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS52037; ZF_RG_C
Name Zinc finger reverse gyrase C-terminal-type
Function Reverse gyrase (RG) is an ATP-dependent topoisomerase that is only found in archaeal and bacterial hyperthermophiles (above 80 degre C) and thermophiles (65-80 degre C). The RG C-terminal-type zinc finger is inserted into the Toprim domain at the base of the DNA-binding site and protrudes from the surface of the topoisomerase domain.
Scope(s) Archaea
Bacteria
Example(s) O29238;

Propagated annotation [?]

Comments [?]

case (<Feature:PS52037:4=[CH]> and <Feature:PS52037:7=[CH]> and <Feature:PS52037:18=[CH]> and <Feature:PS52037:21=[CH]>)
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS52037
Key From To Description Tag Condition FTGroup
case (<Feature:PS52037:4=[C]> and <Feature:PS52037:7=[C]> and <Feature:PS52037:18=[C]> and <Feature:PS52037:21=[C]>)
ZN_FING from to /note="RG C-terminal-type #"
else case (<Feature:PS52037:4=[CH]> and <Feature:PS52037:7=[CH]> and <Feature:PS52037:18=[CH]> and <Feature:PS52037:21=[CH]>)
ZN_FING from to /note="RG C-terminal-type #; atypical"
else
ZN_FING from to /note="RG C-terminal-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 18 18 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 21 21 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 28-30 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]