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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01381


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01381
General rule information [?]

Accession PRU01381
Dates 13-SEP-2023 (Created)
13-SEP-2023 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52037; ZF_RG_C
Name Zinc finger reverse gyrase C-terminal-type
Function Reverse gyrase (RG) is an ATP-dependent topoisomerase that is only found in archaeal and bacterial hyperthermophiles (above 80 degre C) and thermophiles (65-80 degre C). The RG C-terminal-type zinc finger is inserted into the Toprim domain at the base of the DNA-binding site and protrudes from the surface of the topoisomerase domain.
Scope(s) Archaea
Bacteria
Example(s) O29238;

Propagated annotation [?]

Comments [?]

case (<Feature:PS52037:4=[CH]> and <Feature:PS52037:7=[CH]> and <Feature:PS52037:18=[CH]> and <Feature:PS52037:21=[CH]>)
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS52037
Key From To Description Tag Condition FTGroup
case (<Feature:PS52037:4=[C]> and <Feature:PS52037:7=[C]> and <Feature:PS52037:18=[C]> and <Feature:PS52037:21=[C]>)
ZN_FING from to /note="RG C-terminal-type #"
else case (<Feature:PS52037:4=[CH]> and <Feature:PS52037:7=[CH]> and <Feature:PS52037:18=[CH]> and <Feature:PS52037:21=[CH]>)
ZN_FING from to /note="RG C-terminal-type #; atypical"
else
ZN_FING from to /note="RG C-terminal-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 18 18 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 21 21 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 28-30 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]