ProRule PRU01384

General rule information [?]

Accession PRU01384
Dates 5-OCT-2023 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS52040; TOPO_IIA
Name Topoisomerase (Topo) IIA-type catalytic domain
Function Type IIA enzymes include topoisomerase II (topo II) encoded by both eukaryotes and viruses, and DNA gyrase and topoisomerase IV (topo IV) encoded by bacteria. The Topo IIA-type catalytic domain containing the active site tyrosine involved in the covalent complex with DNA is located on the C- terminal region of eukaryal enzymes or on the A-subunit of bacterial enzymes (GyrA or ParC for gyrase and Topo IV respectively).
Scope(s) Bacteria
Example(s) P0C1U9 (PARC_STAAU);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTTag:act_site>
Protein name + AltName: EC=;
end case

Comments [?]

case <FTTag:act_site>
CATALYTIC ACTIVITYReaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=;
end case

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
case <FTTag:act_site>
GO:0006265; Biological process:DNA topological change

Features [?]

From: PS52040
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Topo IIA-type catalytic #"
ACT_SITE 93 93 /note="O-(5'-phospho-DNA)-tyrosine intermediate" act_site Y

Additional information [?]

Size range 60-890 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]