ProRule PRU01384
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PURL: https://purl.expasy.org/prosite/rule/PRU01384
General rule information
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| Accession | PRU01384 |
| Dates | 05-OCT-2023 (Created)
05-OCT-2023 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52040; TOPO_IIA |
Name | Topoisomerase (Topo) IIA-type catalytic domain |
| Function | Type IIA enzymes include topoisomerase II (topo II) encoded by both eukaryotes and viruses, and DNA gyrase and topoisomerase IV (topo IV) encoded by bacteria. The Topo IIA-type catalytic domain containing the active site tyrosine involved in the covalent complex with DNA is located on the C- terminal region of eukaryal enzymes or on the A-subunit of bacterial enzymes (GyrA or ParC for gyrase and Topo IV respectively). |
| Scope(s) |
Bacteria Eukaryota Viruses Archaea Haloferacaceae |
| Example(s) | P0C1U9 (PARC_STAAU); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTTag:act_site> | |
| Protein name | + AltName: EC=5.6.2.2; |
| end case | |
Comments
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| case <FTTag:act_site> | |
| CATALYTIC ACTIVITY | Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
| end case | |
Keywords
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| Isomerase | |
| Topoisomerase | |
| end case | |
| DNA-binding | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding | |
| case <FTTag:act_site> | |
| GO:0006265; Biological process:DNA topological change | |
Features
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| From: PS52040 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Topo IIA-type catalytic #" | |||||||||
| ACT_SITE | 93 | 93 | /note="O-(5'-phospho-DNA)-tyrosine intermediate" | act_site | Y | |||||||
Additional information
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| Size range | 60-890 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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