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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01388


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01388
General rule information [?]

Accession PRU01388
Dates 12-APR-2024 (Created)
12-APR-2024 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52043; UBR4_E3
Name UBR4 E3 catalytic module
Function The UBR4 E3 catalytic module that carries out ubiquitin (Ub) transfer consists of a 'hemiRING' zinc finger, a helical-rich UBR zinc-finger interacting (UZI) subdomain, and an N-terminal region that can serve as an affinity factor for the E2 conjugating enzyme (E2).
Scope(s) Eukaryota
Example(s) Q9VLT5;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the UBR4 family.

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case <Feature:PS52043:133=[CH]> and <Feature:PS52043:136=[CH]> and <Feature:PS52043:183=[CH]> and <Feature:PS52043:186=[CH]>
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding
GO:0006511; Biological process:ubiquitin-dependent protein catabolic process
GO:0004842; Molecular function:ubiquitin-protein transferase activity

Features [?]

From: PS52043
Key From To Description Tag Condition FTGroup
REGION from to /note="UBR4 E3 catalytic module #"
case <Feature:PS52043:133=[C]> and <Feature:PS52043:136=[C]> and <Feature:PS52043:183=[H]> and <Feature:PS52043:186=[C]>
ZN_FING 130 249 /note="HemiRING-type #"
else case <Feature:PS52043:133=[CH]> and <Feature:PS52043:136=[CH]> and <Feature:PS52043:183=[CH]> and <Feature:PS52043:186=[CH]>
ZN_FING 130 249 /note="HemiRING-type #; atypical"
else
ZN_FING 130 249 /note="HemiRING-type #; degenerate"
end case
BINDING 133 133 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 136 136 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 183 183 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 186 186 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
DOMAIN 252 to /note="UZI #"

Additional information [?]

Size range 466-531 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]