ProRule PRU01388
General rule information
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| Accession | PRU01388 |
| Dates | 12-APR-2024 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52043; UBR4_E3 |
Name | UBR4 E3 catalytic module |
| Function | The UBR4 E3 catalytic module that carries out ubiquitin (Ub) transfer consists of a 'hemiRING' zinc finger, a helical-rich UBR zinc-finger interacting (UZI) subdomain, and an N-terminal region that can serve as an affinity factor for the E2 conjugating enzyme (E2). |
| Scope(s) |
Eukaryota |
| Example(s) | Q9VLT5 (POE_DROME); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the UBR4 family. |
Keywords
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| Metal-binding | |
| Zinc | |
| end case | |
| Zinc-finger | |
Gene Ontology
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| case <Feature:PS52043:133=[CH]> and <Feature:PS52043:136=[CH]> and <Feature:PS52043:183=[CH]> and <Feature:PS52043:186=[CH]> | |
| GO:0046872; Molecular function:metal ion binding | |
| GO:0008270; Molecular function:zinc ion binding | |
| GO:0006511; Biological process:ubiquitin-dependent protein catabolic process | |
| GO:0004842; Molecular function:ubiquitin-protein transferase activity | |
Features
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| From: PS52043 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | from | to | /note="UBR4 E3 catalytic module #" | |||||||||
| case <Feature:PS52043:133=[C]> and <Feature:PS52043:136=[C]> and <Feature:PS52043:183=[H]> and <Feature:PS52043:186=[C]> | ||||||||||||
| ZN_FING | 130 | 249 | /note="HemiRING-type #" | |||||||||
| else case <Feature:PS52043:133=[CH]> and <Feature:PS52043:136=[CH]> and <Feature:PS52043:183=[CH]> and <Feature:PS52043:186=[CH]> | ||||||||||||
| ZN_FING | 130 | 249 | /note="HemiRING-type #; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | 130 | 249 | /note="HemiRING-type #; degenerate" | |||||||||
| end case | ||||||||||||
| BINDING | 133 | 133 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 136 | 136 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 183 | 183 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 186 | 186 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| DOMAIN | 252 | to | /note="UZI #" | |||||||||
Additional information
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| Size range | 466-531 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [8] All [ 8 ]
- Retrieve set of proteins with 3D structure for this domain