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ProRule PRU01388


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PURL: https://purl.expasy.org/prosite/rule/PRU01388
General rule information [?]

Accession PRU01388
Dates 12-APR-2024 (Created)
12-APR-2024 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS52043; UBR4_E3
Name UBR4 E3 catalytic module
Function The UBR4 E3 catalytic module that carries out ubiquitin (Ub) transfer consists of a 'hemiRING' zinc finger, a helical-rich UBR zinc-finger interacting (UZI) subdomain, and an N-terminal region that can serve as an affinity factor for the E2 conjugating enzyme (E2).
Scope(s) Eukaryota
Example(s) Q9VLT5;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the UBR4 family.

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case <Feature:PS52043:133=[CH]> and <Feature:PS52043:136=[CH]> and <Feature:PS52043:183=[CH]> and <Feature:PS52043:186=[CH]>
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding
GO:0006511; Biological process:ubiquitin-dependent protein catabolic process
GO:0004842; Molecular function:ubiquitin-protein transferase activity

Features [?]

From: PS52043
Key From To Description Tag Condition FTGroup
REGION from to /note="UBR4 E3 catalytic module #"
case <Feature:PS52043:133=[C]> and <Feature:PS52043:136=[C]> and <Feature:PS52043:183=[H]> and <Feature:PS52043:186=[C]>
ZN_FING 130 249 /note="HemiRING-type #"
else case <Feature:PS52043:133=[CH]> and <Feature:PS52043:136=[CH]> and <Feature:PS52043:183=[CH]> and <Feature:PS52043:186=[CH]>
ZN_FING 130 249 /note="HemiRING-type #; atypical"
else
ZN_FING 130 249 /note="HemiRING-type #; degenerate"
end case
BINDING 133 133 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 136 136 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 183 183 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 186 186 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
DOMAIN 252 to /note="UZI #"

Additional information [?]

Size range 466-531 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]