PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01391


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01391
General rule information [?]

Accession PRU01391
Dates 03-JUL-2024 (Created)
04-JUL-2024 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS52046; ZF_C2HC_NPR
Name Zinc finger C2HC NPR-type
Function A prominent feature of NPR proteins is the presence of a conserved cysteine cluster within the BTB domain. These cysteine residues together with a conserved histidine (C-X-D-X(2,3)-C-X-H-X(2)-C) form a zinc finger motif that bridges the BTB domain with the ANKs.
Scope(s) Eukaryota
Magnoliopsida
Example(s) P93002;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS52046
Key From To Description Tag Condition FTGroup
case <Feature:PS52046:4=[C]> and <Feature:PS52046:9=[C]> and <Feature:PS52046:11=[H]> and <Feature:PS52046:14=[C]>
ZN_FING from to /note="C2HC NPR-type #"
else case <Feature:PS52046:4=[CH]> and <Feature:PS52046:9=[CH]> and <Feature:PS52046:11=[HC]> and <Feature:PS52046:14=[CH]>
ZN_FING from to /note="C2HC NPR-type #; atypical"
else
ZN_FING from to /note="C2HC NPR-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 11 11 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 14 14 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
MOD_RES 10 10 /note="S-nitrosocysteine" C

Additional information [?]

Size range 15-15 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]