ProRule PRU01392
General rule information
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| Accession | PRU01392 |
| Dates | 18-JUL-2024 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52047; I_EGF_2 |
Name | Integrins beta chain EGF (I-EGF) domain |
| Function | The C-terminus of the extracellular region of all the integrin beta chains has four cysteine-rich tandem repeats of forty amino acids, which are variants of the EGF-like domain, termed integrin- or I-EGF domains. I-EGF repeats in the integrin beta subunit stalk region relay activation signals to the ligand-binding headpiece. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q64632 (ITB4_RAT); |
Propagated annotation
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Keywords
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| Integrin | |
| EGF-like domain | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Cross-references
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| PROSITE | PS00243; I_EGF_1; 1; |
Features
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| From: PS52047 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="I-EGF #" | |||||||||
| DISULFID | 1 | 22 | disulf | C-x*-C | ||||||||
| DISULFID | 6 | 20 | disulf | C-x*-C | ||||||||
| DISULFID | 14 | 25 | disulf | C-x*-C | ||||||||
| DISULFID | 27 | 36 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 34-55 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 3-10 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [50] All [ 50 ]
- Retrieve set of proteins with 3D structure for this domain