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ProRule PRU01392


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PURL: https://purl.expasy.org/prosite/rule/PRU01392
General rule information [?]

Accession PRU01392
Dates 18-JUL-2024 (Created)
18-JUL-2024 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52047; I_EGF_2
Name Integrins beta chain EGF (I-EGF) domain
Function The C-terminus of the extracellular region of all the integrin beta chains has four cysteine-rich tandem repeats of forty amino acids, which are variants of the EGF-like domain, termed integrin- or I-EGF domains. I-EGF repeats in the integrin beta subunit stalk region relay activation signals to the ligand-binding headpiece.
Scope(s) Eukaryota
Metazoa
Example(s) Q64632 (ITB4_RAT);

Propagated annotation [?]

Keywords [?]

Integrin
EGF-like domain
case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS00243; I_EGF_1; 1;

Features [?]

From: PS52047
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="I-EGF #"
DISULFID 1 22 disulf C-x*-C
DISULFID 6 20 disulf C-x*-C
DISULFID 14 25 disulf C-x*-C
DISULFID 27 36 disulf C-x*-C

Additional information [?]

Size range 34-55 amino acids
Related rules None
Fusion None
Repeats 3-10
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]