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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01392


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01392
General rule information [?]

Accession PRU01392
Dates 18-JUL-2024 (Created)
18-JUL-2024 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52047; I_EGF_2
Name Integrins beta chain EGF (I-EGF) domain
Function The C-terminus of the extracellular region of all the integrin beta chains has four cysteine-rich tandem repeats of forty amino acids, which are variants of the EGF-like domain, termed integrin- or I-EGF domains. I-EGF repeats in the integrin beta subunit stalk region relay activation signals to the ligand-binding headpiece.
Scope(s) Eukaryota
Metazoa
Example(s) Q64632;

Propagated annotation [?]

Keywords [?]

Integrin
EGF-like domain
case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS00243; I_EGF_1; 1;

Features [?]

From: PS52047
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="I-EGF #"
DISULFID 1 22 disulf C-x*-C
DISULFID 6 20 disulf C-x*-C
DISULFID 14 25 disulf C-x*-C
DISULFID 27 36 disulf C-x*-C

Additional information [?]

Size range 34-55 amino acids
Related rules None
Fusion None
Repeats 3-10
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]