ProRule PRU01398
General rule information
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| Accession | PRU01398 |
| Dates | 22-OCT-2024 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52053; NEL |
Name | Novel E3 ligase (NEL) domain |
| Function | The ~300 residue NEL domain bears a cysteine residue that mediates transfer of ubiquitin to substrates through the formation of a thioester intermediate, analogous to the structurally unrelated HECT domain in eukaryotes. |
| Scope(s) |
Bacteria Pseudomonadota |
| Example(s) | A0A0H2USC0 (IPA25_SHIFL); |
Propagated annotation
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Comments
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| case <FTTag:act_site> | |
| PTM | Ubiquitinated in the presence of host E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme and ubiquitin. |
| end case | |
| SIMILARITY | Belongs to the LRR-containing bacterial E3 ligase family. |
Keywords
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Gene Ontology
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| GO:0005576; Cellular component:extracellular region | |
| case <FTTag:act_site> | |
| GO:0004842; Molecular function:ubiquitin-protein transferase activity | |
Features
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| From: PS52053 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="NEL #" | |||||||||
| ACT_SITE | 89 | 89 | /note="Glycyl thioester intermediate" | act_site | C | |||||||
Additional information
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| Size range | 280-295 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [17] All [ 17 ]
- Retrieve set of proteins with 3D structure for this domain