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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01404


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01404
General rule information [?]

Accession PRU01404
Dates 13-MAR-2025 (Created)
13-MAR-2025 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52059; BACT_RHOGAP
Name Bacterial Rho GTPase-activating protein (GAP) domain
Function The bacterial toxins ExoS, ExoT, SptP, and YopE are GAPs for various Rho GTPases.
Scope(s) Bacteria
Gammaproteobacteria
Example(s) P31493;

Propagated annotation [?]

Keywords [?]

Virulence
GTPase activation
end case

Gene Ontology [?]

case <Feature:PS52059:48=R>
GO:0005096; Molecular function:GTPase activator activity

Features [?]

From: PS52059
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Bacterial Rho-GAP #"
SITE 48 48 /note="Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state" R

Additional information [?]

Size range 119-134 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]