ProRule PRU01404
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PURL: https://purl.expasy.org/prosite/rule/PRU01404
General rule information
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| Accession | PRU01404 |
| Dates | 13-MAR-2025 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52059; BACT_RHOGAP |
Name | Bacterial Rho GTPase-activating protein (GAP) domain |
| Function | The bacterial toxins ExoS, ExoT, SptP, and YopE are GAPs for various Rho GTPases. |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Example(s) | P31493 (YOPE_YERPE); |
Propagated annotation
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Keywords
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| Virulence | |
| GTPase activation | |
| end case | |
Gene Ontology
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| case <Feature:PS52059:48=R> | |
| GO:0005096; Molecular function:GTPase activator activity | |
Features
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| From: PS52059 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Bacterial Rho-GAP #" | |||||||||
| SITE | 48 | 48 | /note="Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state" | R | ||||||||
Additional information
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| Size range | 119-134 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [9] All [ 9 ]
- Retrieve set of proteins with 3D structure for this domain