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ProRule PRU01406


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PURL: https://purl.expasy.org/prosite/rule/PRU01406
General rule information [?]

Accession PRU01406
Dates 08-APR-2025 (Created)
08-APR-2025 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS52061; DAHPS_I
Name DAHPS class-I core TIM-barrel domain
Function Although there is no significant sequence similarity between the class-II DAHPSs and the class-I DAHPSs and KDOPSs, they share a characteristic (beta/alpha)8 TIM-barrel fold in which the eight parallel beta-strands are each followed by alpha-helices, and similar active site architecture.
Scope(s) Bacteria
Eukaryota
Example(s) A1US93;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the class-I DAHP synthase family.

Keywords [?]

Cytoplasm
case <FTGroup:1> and (<FTGroup:2> or <FTGroup:3>)
Transferase
else case <FTGroup:1>
Metal-binding
end case

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm

Features [?]

case <FTGroup:1> and (<FTGroup:2> or <FTGroup:3>)
From: PS52061
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="DAHPS class-I TIM-barrel #"
BINDING 11 11 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"		 C 1
BINDING 36 36 /ligand="phosphoenolpyruvate"
/ligand_id="ChEBI:CHEBI:58702"		 [KR] 2
BINDING 41 41 /ligand="phosphoenolpyruvate"
/ligand_id="ChEBI:CHEBI:58702"		 K 2
case not <FTGroup:2>
BINDING 94 94 /ligand="phosphoenolpyruvate"
/ligand_id="ChEBI:CHEBI:58702"		 Q 3
end case
BINDING 97 97 /ligand="phosphoenolpyruvate"
/ligand_id="ChEBI:CHEBI:58702"		 A 2
BINDING 98 98 /ligand="phosphoenolpyruvate"
/ligand_id="ChEBI:CHEBI:58702"		 R 2
BINDING 119 119 /ligand="phosphoenolpyruvate"
/ligand_id="ChEBI:CHEBI:58702"		 K 2
BINDING 149 149 /ligand="phosphoenolpyruvate"
/ligand_id="ChEBI:CHEBI:58702"		 R 2
BINDING 184 184 /ligand="phosphoenolpyruvate"
/ligand_id="ChEBI:CHEBI:58702"		 H 2
BINDING 184 184 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"		 H 1
BINDING 210 210 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"		 E 1
BINDING 221 221 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"		 D 1

Additional information [?]

Size range 124-312 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]