We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01406
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01406
General rule information
[?]
| Accession | PRU01406 |
| Dates | 08-APR-2025 (Created)
08-APR-2025 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52061; DAHPS_I |
Name | DAHPS class-I core TIM-barrel domain |
| Function | Although there is no significant sequence similarity between the class-II DAHPSs and the class-I DAHPSs and KDOPSs, they share a characteristic (beta/alpha)8 TIM-barrel fold in which the eight parallel beta-strands are each followed by alpha-helices, and similar active site architecture. |
| Scope(s) |
Bacteria Eukaryota |
| Example(s) | A1US93; |
Propagated annotation
[?]
Comments
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| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class-I DAHP synthase family. |
Keywords
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| Cytoplasm | |
| case <FTGroup:1> and (<FTGroup:2> or <FTGroup:3>) | |
| Transferase | |
| else case <FTGroup:1> | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0005737; Cellular component:cytoplasm |
Features
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| case <FTGroup:1> and (<FTGroup:2> or <FTGroup:3>) | ||||||||||||
| From: PS52061 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="DAHPS class-I TIM-barrel #" | |||||||||
| BINDING | 11 | 11 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
C | 1 | |||||||
| BINDING | 36 | 36 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
[KR] | 2 | |||||||
| BINDING | 41 | 41 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
K | 2 | |||||||
| case not <FTGroup:2> | ||||||||||||
| BINDING | 94 | 94 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
Q | 3 | |||||||
| end case | ||||||||||||
| BINDING | 97 | 97 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
A | 2 | |||||||
| BINDING | 98 | 98 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
R | 2 | |||||||
| BINDING | 119 | 119 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
K | 2 | |||||||
| BINDING | 149 | 149 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
R | 2 | |||||||
| BINDING | 184 | 184 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
H | 2 | |||||||
| BINDING | 184 | 184 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
H | 1 | |||||||
| BINDING | 210 | 210 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
E | 1 | |||||||
| BINDING | 221 | 221 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | 1 | |||||||
Additional information
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| Size range | 124-312 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.