ProRule PRU01407
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01407
General rule information
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| Accession | PRU01407 |
| Dates | 04-APR-2025 (Created)
07-APR-2025 (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52062; DAHPS_II |
Name | DAHPS class-II core TIM-barrel domain |
| Function | Although there is no significant sequence similarity between the class-II DAHPSs and the class-I DAHPSs and KDOPSs, they share a characteristic (beta/alpha)8 TIM-barrel fold in which the eight parallel beta-strands are each followed by alpha-helices, and similar active site architecture. |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | P21357; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the class-II DAHP synthase family. |
Keywords
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| case <FTGroup:1> and <FTGroup:2> | |
| Transferase | |
| Metal-binding | |
| end case | |
Features
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| From: PS52062 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="DAHPS class-II TIM-barrel #" | |||||||||
| BINDING | 11 | 11 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
C | 1 | |||||||
| BINDING | 50 | 50 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
R | 2 | |||||||
| BINDING | 208 | 208 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
[ED] | 2 | |||||||
| BINDING | 209 | 209 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
R | 2 | |||||||
| BINDING | 231 | 231 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
K | 2 | |||||||
| BINDING | 262 | 262 | /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702" |
R | 2 | |||||||
| BINDING | 294 | 294 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
H | 1 | |||||||
| BINDING | 336 | 336 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
E | 1 | |||||||
| BINDING | 366 | 366 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
D | 1 | |||||||
Additional information
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| Size range | 18-415 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [7] Eukaryota [13] All [ 20 ]
- Retrieve set of proteins with 3D structure for this domain