We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01410
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01410
General rule information
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| Accession | PRU01410 |
| Dates | 12-JUN-2025 (Created)
12-JUN-2025 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50051; MCM_CTD |
Name | MCM family C-terminal AAA(+) ATPase domain (MCM-CTD) |
| Function | The MCM-CTD contains the canonical Walker A (WA) motif to localize binding of nucleoside triphosphates (NTPs), the Walker B (WB) motif to hydrolyze NTPs, and two DNA binding loops for DNA translocation. |
| Scope(s) |
Eukaryota Archaea |
| Example(s) | Q6NRM6; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the MCM family. |
Keywords
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| Nucleus | |
| end case | |
| ATP-binding | |
| DNA-binding | |
| Nucleotide-binding | |
| DNA replication | |
| Cell cycle | |
| case <Feature:PS50051:201=R> | |
| Helicase | |
| Hydrolase | |
| end case | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| case <Feature:PS50051:201=R> | |
| GO:0016887; Molecular function:ATP hydrolysis activity | |
| end case | |
| GO:0042555; Cellular component:MCM complex | |
| case <OCellular component:Eukaryota> | |
| GO:0005634; Cellular component:nucleus | |
Features
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| From: PS50051 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="MCM C-terminal AAA(+) ATPase #" | |||||||||
| MOTIF | 68 | 75 | /note="Walker A #" | |||||||||
| MOTIF | 132 | 135 | /note="Walker B #" | |||||||||
| SITE | 201 | 201 | /note="Arginine finger #" | R | ||||||||
Additional information
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| Size range | 328-402 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [5] Eukaryota [107] All [ 112 ]
- Retrieve set of proteins with 3D structure for this domain