PROSITE logo

ProRule PRU01410


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01410
General rule information [?]

Accession PRU01410
Dates 12-JUN-2025 (Created)
12-JUN-2025 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS50051; MCM_CTD
Name MCM family C-terminal AAA(+) ATPase domain (MCM-CTD)
Function The MCM-CTD contains the canonical Walker A (WA) motif to localize binding of nucleoside triphosphates (NTPs), the Walker B (WB) motif to hydrolyze NTPs, and two DNA binding loops for DNA translocation.
Scope(s) Eukaryota
Archaea
Example(s) Q6NRM6;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the MCM family.

Keywords [?]

Nucleus
end case
ATP-binding
DNA-binding
Nucleotide-binding
DNA replication
Cell cycle
case <Feature:PS50051:201=R>
Helicase
Hydrolase
end case

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
case <Feature:PS50051:201=R>
GO:0016887; Molecular function:ATP hydrolysis activity
end case
GO:0042555; Cellular component:MCM complex
case <OCellular component:Eukaryota>
GO:0005634; Cellular component:nucleus

Features [?]

From: PS50051
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MCM C-terminal AAA(+) ATPase #"
MOTIF 68 75 /note="Walker A #"
MOTIF 132 135 /note="Walker B #"
SITE 201 201 /note="Arginine finger #" R

Additional information [?]

Size range 328-402 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]