ProRule PRU01412

Accession	PRU01412
Dates	05-JUN-2025 (Created) 05-JUN-2025 (Last updated, Version )
Data class	Domain;
Predictors	PROSITE; PS52066; MCM10_CTD
Name	MCM10 C-terminal domain (MCM10-CTD)
Function	The MCM10 CTD, although not present in unicellular eukaryotes, is conserved among metazoan species from nematodes to humans. The CTD contains a winged helix domain (WH) and two zinc chelating motifs, a CCCH zinc-finger (ZnF2) and a CCCC zinc-ribbon (ZnR). ssDNA binds only to ZnF2, whose structure is unique to MCM10. The ZnR is not involved in DNA binding.
Scope(s)	Eukaryota Metazoa
Example(s)	Q5EAW4;

From: PS52066
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="MCM10-CTD #"
REGION	from	64	/note="Winged helix (WH) #"
case <Feature:PS52066:74=[C]> and <Feature:PS52066:77=[C]> and <Feature:PS52066:88=[C]> and <Feature:PS52066:93=[H]>
REGION	65	101	/note="CCCH-type zinc finger (ZnF2) #"
else case <FTGroup:1>
REGION	65	101	/note="CCCH-type zinc finger (ZnF2) #; atypical"
else
REGION	65	101	/note="CCCH-type zinc finger (ZnF2) #; degenerate"
end case
case <Feature:PS52066:107=[C]> and <Feature:PS52066:110=[C]> and <Feature:PS52066:125=[C]> and <Feature:PS52066:128=[C]>
REGION	102	139	/note="CCCC-type zinc ribbon (ZnR) #"
else case <FTGroup:2>
REGION	102	139	/note="CCCC-type zinc ribbon (ZnR) #; atypical"
else
REGION	102	139	/note="CCCC-type zinc ribbon (ZnR) #; degenerate"
end case
BINDING	74	74	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	77	77	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	88	88	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	93	93	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1"		[CH]	1
BINDING	107	107	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2
BINDING	110	110	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2
BINDING	125	125	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2
BINDING	128	128	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2"		[CH]	2