We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01416
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01416
General rule information
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| Accession | PRU01416 |
| Dates | 30-JUN-2025 (Created)
30-JUN-2025 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52071; GPN_LOOP_GTPASE |
Name | GPN-loop GTPase domain |
| Function | GPN-loop GTPases are assembly chaperones for RNA polymerase II (Pol II) and other protein complexes. This family of conserved GTPases has been named GPN-loop GTPases due to the presence of a conserved Gly-Pro-Asn motif inserted into the GTPase core-fold. GPN-loop GTPases form homo- and heterodimers. |
| Scope(s) |
Eukaryota Archaea Pyrococcus |
| Example(s) | Q4V7Z0; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the GPN-loop GTPase family. |
Keywords
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| GTP-binding | |
| Hydrolase | |
| Nucleotide-binding | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0005525; Molecular function:GTP binding | |
| GO:0003924; Molecular function:GTPase activity | |
Features
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| From: PS52071 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="GPN-loop core GTPase #" | |||||||||
| MOTIF | 9 | 16 | /note="G1 #" | G-x(2)-[GS]-x-G-K-[TS] | 1 | |||||||
| case <Feature:PS52071:36-39=[VIL]-N-[LM]-D> | ||||||||||||
| MOTIF | 36 | 39 | /note="G2 #" | 1 | ||||||||
| else case <Feature:PS52071:35-39=[VIL]-x(0,1)-N-[LM]-D> | ||||||||||||
| MOTIF | 35 | 39 | /note="G2 #" | 1 | ||||||||
| end case | ||||||||||||
| MOTIF | 69 | 71 | /note="Gly-Pro-Asn (GPN)-loop; involved in dimer interface" | G-P-N | ||||||||
| MOTIF | 103 | 107 | /note="G3 #" | D-x-P-G-Q | 1 | |||||||
| MOTIF | 170 | 173 | /note="G4 #" | [NST]-K-x-D | 1 | |||||||
| MOTIF | 228 | 230 | /note="G5 #" | 1 | ||||||||
Additional information
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| Size range | 247-284 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.