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ProRule PRU01416


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PURL: https://purl.expasy.org/prosite/rule/PRU01416
General rule information [?]

Accession PRU01416
Dates 30-JUN-2025 (Created)
30-JUN-2025 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS52071; GPN_LOOP_GTPASE
Name GPN-loop GTPase domain
Function GPN-loop GTPases are assembly chaperones for RNA polymerase II (Pol II) and other protein complexes. This family of conserved GTPases has been named GPN-loop GTPases due to the presence of a conserved Gly-Pro-Asn motif inserted into the GTPase core-fold. GPN-loop GTPases form homo- and heterodimers.
Scope(s) Eukaryota
Archaea
Pyrococcus
Example(s) Q4V7Z0;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the GPN-loop GTPase family.

Keywords [?]

GTP-binding
Hydrolase
Nucleotide-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity

Features [?]

From: PS52071
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="GPN-loop core GTPase #"
MOTIF 9 16 /note="G1 #" G-x(2)-[GS]-x-G-K-[TS] 1
case <Feature:PS52071:36-39=[VIL]-N-[LM]-D>
MOTIF 36 39 /note="G2 #" 1
else case <Feature:PS52071:35-39=[VIL]-x(0,1)-N-[LM]-D>
MOTIF 35 39 /note="G2 #" 1
end case
MOTIF 69 71 /note="Gly-Pro-Asn (GPN)-loop; involved in dimer interface" G-P-N
MOTIF 103 107 /note="G3 #" D-x-P-G-Q 1
MOTIF 170 173 /note="G4 #" [NST]-K-x-D 1
MOTIF 228 230 /note="G5 #" 1

Additional information [?]

Size range 247-284 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]