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ProRule PRU01417


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PURL: https://purl.expasy.org/prosite/rule/PRU01417
General rule information [?]

Accession PRU01417
Dates 09-JUL-2025 (Created)
09-JUL-2025 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS52072; VPS10P
Name Vacuolar protein sorting 10 protein (Vps10p) domain
Function The Vps10p domain is formed by three structural units: a large N- terminal beta-propeller and two cysteine-knots called 10CCa and 10CCb, which constitute the so-called 10CC (ten conserved cysteines) module. The Vps10p propeller has a wide, open tunnel lined by ten edge strands running parallel to the propeller axis, thus providing ample opportunity for beta-sheet extension to capture extended peptides threaded into the tunnel. The C- terminal elongated 10CC module that partly wraps around the 'bottom' face of the propeller contains five conserved disulfide bridges and is a major ligand-binding region.
Scope(s) Eukaryota
Example(s) Q92673;

Propagated annotation [?]

Keywords [?]

Receptor
Transport
Protein transport
case <FTTag:disulf>
Disulfide bond
end case

Features [?]

From: PS52072
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Vps10p #"
REGION from 519 /note="10-bladed beta-propeller #"
REGION 527 579 /note="10CCa cysteine-knot #"
REGION 581 to /note="10CCb cysteine-knot #"
DISULFID 369 376 disulf C-x*-C
DISULFID 527 563 disulf C-x*-C
DISULFID 546 579 disulf C-x*-C
DISULFID 581 635 disulf C-x*-C
DISULFID 588 600 disulf C-x*-C
DISULFID 613 650 disulf C-x*-C

Additional information [?]

Size range 133-728 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]