We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01417
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01417
General rule information
[?]
| Accession | PRU01417 |
| Dates | 09-JUL-2025 (Created)
09-JUL-2025 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52072; VPS10P |
Name | Vacuolar protein sorting 10 protein (Vps10p) domain |
| Function | The Vps10p domain is formed by three structural units: a large N- terminal beta-propeller and two cysteine-knots called 10CCa and 10CCb, which constitute the so-called 10CC (ten conserved cysteines) module. The Vps10p propeller has a wide, open tunnel lined by ten edge strands running parallel to the propeller axis, thus providing ample opportunity for beta-sheet extension to capture extended peptides threaded into the tunnel. The C- terminal elongated 10CC module that partly wraps around the 'bottom' face of the propeller contains five conserved disulfide bridges and is a major ligand-binding region. |
| Scope(s) |
Eukaryota |
| Example(s) | Q92673; |
Propagated annotation
[?]
Keywords
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| Receptor | |
| Transport | |
| Protein transport | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Features
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| From: PS52072 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Vps10p #" | |||||||||
| REGION | from | 519 | /note="10-bladed beta-propeller #" | |||||||||
| REGION | 527 | 579 | /note="10CCa cysteine-knot #" | |||||||||
| REGION | 581 | to | /note="10CCb cysteine-knot #" | |||||||||
| DISULFID | 369 | 376 | disulf | C-x*-C | ||||||||
| DISULFID | 527 | 563 | disulf | C-x*-C | ||||||||
| DISULFID | 546 | 579 | disulf | C-x*-C | ||||||||
| DISULFID | 581 | 635 | disulf | C-x*-C | ||||||||
| DISULFID | 588 | 600 | disulf | C-x*-C | ||||||||
| DISULFID | 613 | 650 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 133-728 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.