ProRule PRU01419
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01419
General rule information
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| Accession | PRU01419 |
| Dates | -- (Created)
-- (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52074; COV_4ECTO |
Name | Coronavirus Nsp4 ectodomain (4Ecto) |
| Function | Nsp4 contains six transmembranes with its ectodomain (4Ecto) localized in the intermembrane space and its carboxy-terminal domain (CTD) in the DMV lumen, forming two layers of concentric stacking hexamers constituting the lower base of the pore complex. The 3Ecto domain attaches to the upper surface of the 4Ecto domain, which is mediated by a combination of hydrophobic and hydrophilic interactions. |
| Scope(s) |
Viruses Orthocoronavirinae |
| Example(s) | P0C6T5; |
Propagated annotation
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Comments
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| FUNCTION | [Non-structural protein 4]: Plays a role in the formation and maintenance of double membrane vesicles (DMVs) replication organelles. DMVs are formed by nsp3 and nsp4, while nsp6 zippers ER membranes and connects to lipid droplets. |
| SIMILARITY | Belongs to the coronaviruses polyprotein 1ab family. |
Features
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| From: PS52074 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="4Ecto #" | |||||||||
Additional information
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| Size range | 235-252 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [59] All [ 59 ]
- Retrieve set of proteins with 3D structure for this domain