ProRule PRU01423
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01423
General rule information
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| Accession | PRU01423 |
| Dates | -- (Created)
-- (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52078; IFN_IV |
Name | Interferon (IFN) type-IV family |
| Function | IFN-upsilon (IFNU), the type IV IFN, is found in jawed vertebrates ranging from cartilaginous fish to primitive mammals. It differs from type I, II, and III IFNs in consideration of sequence feature, gene locus, phylogeny, and receptor complex. IFN-upsilon proteins in vertebrates were reported to contain conserved sequence, CXXXXX(W/L) at N-terminus, being different from other known three types of IFNs. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | A0A6P6J8D3; |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Secreted. |
| SIMILARITY | Belongs to the type-IV (or upsilon) interferon family. |
Keywords
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Gene Ontology
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| GO:0005125; Molecular function:cytokine activity |
| GO:0050778; Biological process:positive regulation of immune response |
| GO:0051607; Biological process:defense response to virus |
| GO:0005615; Cellular component:extracellular space |
| GO:0045087; Biological process:innate immune response |
| GO:0005102; Molecular function:signaling receptor binding |
Cross-references
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| PROSITE | PS00001; ASN_GLYCOSYLATION; 0-1; |
Features
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Additional information
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| Size range | 95-205 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [2] All [ 2 ]
- Retrieve set of proteins with 3D structure for this domain