ProRule PRU01429

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PURL: https://purl.expasy.org/prosite/rule/PRU01429

General rule information [?]

Accession	PRU01429
Dates	-- (Created) -- (Last updated, Version )
Data class	Domain;
Predictors	PROSITE; PS52084; NCOA4_HBD
Name	NCOA4 HERC2-binding domain (HBD)
Function	NCOA4 mainly contains an N-terminal coiled-coil domain that mediates the self-polymerization of NCOA4, a HECT and RLD-containing E3 ubiquitin protein ligase 2 (HERC2)-binding domain (HBD), and a C-terminal ferritin- binding motif (FBM). The HBD of NCOA4 sense the cellular iron level and is responsible for binding to HERC2 in an iron-sulfur cluster-dependent manner.
Scope(s)	Eukaryota Euteleostomi
Example(s)	Q802X2;

Propagated annotation [?]

Keywords [?]

2Fe-2S
Iron
Iron-sulfur
Metal-binding
end case
Cytoplasmic vesicle
Lysosome

Gene Ontology [?]

GO:0044754; Cellular component:autolysosome
GO:0005776; Cellular component:autophagosome
GO:0006879; Biological process:intracellular iron ion homeostasis
GO:0031410; Cellular component:cytoplasmic vesicle
case <FTGroup:1>
GO:0051537; Molecular function:2 iron, 2 sulfur cluster binding
GO:0005506; Molecular function:iron ion binding

Features [?]

From: PS52084

Key

From

Description

Tag

Condition

FTGroup

DOMAIN

from

/note="NCOA4 HERC2-binding (HBD) #"

BINDING

/ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
/ligand_label="#1"

BINDING

/ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
/ligand_label="#1"

BINDING

/ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
/ligand_label="#1"

BINDING

/ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
/ligand_label="#1"

Additional information [?]

Size range	57-61 amino acids
Related rules	None
Fusion	None
Repeats	1
Topology	Undefined

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