PROSITE entry PS52084
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PURL: https://purl.expasy.org/prosite/signature/PS52084
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General information about the entry
| Entry name [info] | NCOA4_HBD |
| Accession [info] | PS52084 |
| Entry type [info] | MATRIX |
| Date [info] |
10-JUN-2026 CREATED;
10-JUN-2026 DATA UPDATE; 10-JUN-2026 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC52084 |
| Associated ProRule [info] | PRU01429 |
Name and characterization of the entry
| Description [info] | NCOA4 HERC2-binding domain (HBD) profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=63; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=58; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.7996895; R2=0.0097123; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1051; N_SCORE=12.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=484; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-29; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='I'; M= 3, 22, 5, -19, -67, 9, -67, 33, -10, -18, -56, -2, 23, 1, -65, 16, 31, -4, -80, -67; /M: SY='P'; M= -1, -72, -59, -55, -67, -62, -59, -13, 37, -22, -61, 25, 52, 2, -54, 43, 30, -61, -74, 17; /M: SY='Q'; M= -13, 25, 27, 41, -73, -67, -59, -64, -12, -17, 13, -53, 1, 54, -57, 19, 37, -16, -82, -66; /M: SY='D'; M= -7, 23, 85, -2, -78, -18, -59, -65, -56, -71, -68, 13, 0, 28, -63, -54, -6, 21, -91, -70; /M: SY='M'; M= -10, 24, 31, -53, -63, -68, -59, -58, 53, 14, 53, -55, 3, 2, -51, 12, -9, -29, -74, 8; /M: SY='Q'; M= -12, -73, -54, 26, 0, 30, -59, -67, 0, -27, -63, 32, 2, 49, -57, 39, -54, -10, -76, -64; /M: SY='R'; M= 23, -75, -7, 16, -76, -66, 31, -71, 31, -71, -63, -53, -68, 32, 67, 12, -57, -9, -78, -63; /M: SY='W'; M= -70, 24, -80, 12, 3, -75, -82, -66, -12, -66, -67, -80, -76, -65, -68, -72, -11, -16, 159, 24; /M: SY='L'; M= -67, -71, -81, -73, 31, -85, -69, 33, -14, 75, -33, -77, -81, 5, -70, -74, -63, -39, -67, -49; /M: SY='M'; M= 7, -72, -60, 15, -63, -67, 30, -6, 32, -9, 49, -56, -67, 33, -7, 28, -4, -18, -73, 12; /I: I=-12; MD=-29; /M: SY='R'; M= -17, 16, 19, 0, -89, -24, 31, -90, -12, -86, -77, -61, -79, 18, 48, 15, -9, -83, -93, -75; D=-12; /I: I=-12; MD=-29; /M: SY='I'; M= -77, -94, -74, 14, -86, 3, -4, 28, -5, -76, 26, 19, 3, -72, -78, -5, -74, -71, -97, -83; D=-12; /I: I=-12; MI=0; MD=-29; IM=0; DM=-29; /M: SY='D'; M= 22, -85, 57, 30, -86, -72, 30, -82, -65, -31, -75, -60, 49, -61, -72, -3, -64, -78, -93, -77; D=-12; /I: I=-12; DM=-29; /M: SY='T'; M= 3, -80, -65, -5, -83, -9, -69, -21, 37, -77, -70, -60, -72, 31, 16, -11, 50, -69, -86, -74; D=-12; /I: I=-12; DM=-29; /M: SY='M'; M= -62, -79, 38, 22, -72, -70, 31, -68, -10, -67, 64, -3, 13, -56, -63, 43, -57, -18, -85, 2; D=-12; /I: I=-12; DM=-29; /M: SY='C'; M= -24, 61, -8, -68, 22, -77, -72, -6, -9, -22, -61, -68, 10, 17, -70, -16, 23, 6, 58, 12; D=-12; /I: I=-12; DM=-29; /M: SY='D'; M= 21, -73, 38, -4, -74, 6, -60, -68, 0, 1, -62, -1, 31, 30, 0, 0, 20, -65, -80, -68; /M: SY='D'; M= 25, -73, 42, 12, -68, 25, -65, -55, -60, 8, 20, -59, 33, -59, -4, -57, -58, 23, -80, -67; /M: SY='P'; M= -19, 17, 5, -61, 20, -17, -67, -6, -11, -27, -60, 10, 62, -62, 16, -2, -9, 12, 51, -59; /M: SY='P'; M= -18, 33, 24, -52, -68, -68, 23, -62, 15, 23, 20, 2, 44, 43, 4, 7, -57, -64, -80, -63; /M: SY='V'; M= -59, -70, -82, -74, 10, -85, -77, 44, -73, 38, -38, -77, -79, 13, -74, -69, -56, 70, -75, -55; /M: SY='E'; M= 19, -74, 1, 63, -75, -16, -57, -70, 17, -24, 28, 6, -63, 30, -7, -9, 3, -66, -79, -67; /M: SY='D'; M= -62, -79, 69, 65, -73, -67, -54, -80, 15, -77, -72, 14, -64, 8, -53, 10, -57, -77, 57, 12; /M: SY='V'; M= 23, -65, -77, -71, -56, -73, -76, -29, -70, 6, 31, -71, -75, -69, -72, -2, -5, 82, -83, -62; /M: SY='C'; M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82; /M: SY='K'; M= -63, -78, -60, -47, -76, -72, -58, -71, 76, -73, -63, -53, 12, 18, 72, -57, 3, -9, -75, -65; /M: SY='A'; M= 92, -62, -67, -61, -76, 14, -69, -67, -63, -68, -62, -60, -66, -60, -68, -41, 5, -54, -76, -72; /M: SY='N'; M= -60, -67, 7, -55, -77, -52, -45, -75, -49, -82, -70, 117, -71, -50, -57, 3, 6, -76, -95, -71; /M: SY='E'; M= -59, -80, -34, 105, -82, -74, -54, -84, -4, -77, -72, -55, -57, -35, 1, -5, -59, -76, -80, -72; /M: SY='P'; M= -58, -73, -67, -59, -67, -72, -70, -9, 41, -21, -55, -62, 72, -61, -58, -1, 36, 46, -80, -67; /M: SY='C'; M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82; /M: SY='Q'; M= 29, -71, 43, -5, -79, -5, -58, -75, 28, -75, -67, -47, -64, 51, -52, 48, 7, -68, -80, -68; /M: SY='S'; M= -14, -67, 7, -56, -74, 14, 31, -72, -10, -74, -67, 14, -64, -54, -61, 68, 61, -65, -85, -65; /M: SY='F'; M= -71, -76, -77, -72, 93, -79, 47, -52, -68, -10, -51, -71, 37, -72, -4, -69, -65, -6, -49, 54; /M: SY='S'; M= 1, -69, 52, -49, -77, -56, -59, -71, 18, -76, -70, 1, 6, -51, -57, 79, -44, -16, -85, -68; /M: SY='E'; M= -13, -79, 58, 77, -82, -68, 31, -82, 32, -77, -71, -48, -61, 20, -48, -13, -58, -76, -83, -67; /M: SY='C'; M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82; /M: SY='V'; M= -8, -68, -83, -77, 9, -82, -81, 34, -75, 18, -40, -78, -78, -75, -76, -67, -54, 83, -78, -56; /M: SY='C'; M= -9, 134, -73, -73, -66, -70, -71, -70, -70, -65, 27, -61, -80, -72, -75, 22, 22, -61, -88, 1; /M: SY='D'; M= -63, -78, 98, 32, -85, -64, -53, -81, -51, -80, -76, 14, -65, 38, -58, -7, 4, -78, -93, -69; /M: SY='P'; M= -58, -79, 22, 52, -78, 24, -61, -9, -55, -70, 17, -55, 61, 31, -62, -1, 18, -67, -80, -71; /M: SY='N'; M= -60, -73, 10, -52, -78, -10, 73, -78, -52, -79, -66, 91, 27, 37, -57, 16, -52, -79, -90, -63; /M: SY='C'; M= -61, 154, -81, -81, -71, -77, -81, -78, -77, -69, -69, -67, -92, -85, -83, -64, -61, -66,-101, -82; /M: SY='Y'; M= 3, 9, -67, -15, 31, 36, 27, -59, 14, 28, -52, -62, -74, 2, -61, -60, -63, -60, -60, 54; /M: SY='D'; M= -64, -78, 52, 18, 22, -9, -56, -67, 25, -8, -60, -53, -70, 33, 47, -59, -61, -22, -70, 19; /M: SY='T'; M= -19, -69, -53, 21, -71, 3, -59, -62, -52, -16, -60, 32, -65, 47, -6, 14, 66, -10, -82, -66; /M: SY='A'; M= 59, 35, -59, 0, 7, -59, 42, -60, -61, -3, -57, 44, -70, -58, -65, -8, -4, -11, -79, -61; /M: SY='W'; M= 0, -73, -1, -7, 9, -69, -61, -7, -59, 37, -49, 10, -3, 34, -6, 16, -57, -16, 45, 5; /I: I=-33; MI=0; MD=-84; IM=0; DM=-84; /M: SY='K'; M= -57, 1, 3, 33, -77, -16, 19, -76, 46, -32, -66, 5, 35, 19, -6, 43, -53, -73, -80, -67; /M: SY='N'; M= -57, -74, 9, 30, -73, 7, 46, -70, 24, -73, -66, 58, -67, -49, -5, 31, -54, 3, 45, -62; /M: SY='W'; M= -64, -77, 25, -5, 23, -74, -67, -57, 16, 9, -57, -62, 32, 1, 0, -61, 27, 5, 98, -51; /M: SY='D'; M= -59, -73, 53, 17, -69, -68, 17, -61, -9, 15, -58, -51, 24, 7, -60, 20, 49, -19, -84, -64; /M: SY='Q'; M= 21, 34, 0, -3, -68, 4, 22, -11, -57, 13, -56, -55, -69, 46, -6, 20, 23, -58, -79, -64; /M: SY='Y'; M= -55, -72, -60, -4, -62, -22, -61, -55, 33, -63, -58, -56, 27, 37, -54, 29, 37, 35, -71, 38; /M: SY='Q'; M= -15, -76, 16, 0, -7, -66, -55, -65, 45, 14, -58, 48, 28, 60, -48, -55, -57, -67, -76, -62; /M: SY='K'; M= -60, -74, 34, 23, -72, -66, -59, -71, 58, -27, -66, 27, 13, -49, -48, 0, 44, -69, 57, -64; /M: SY='W'; M= 24, 10, -69, -65, -2, 12, -69, 43, -64, 2, -52, -4, 1, 35, -68, 10, -7, -49, 57, -58; /M: SY='W'; M= -20, -76, -1, 41, -68, -22, -61, -62, 0, 6, -59, -3, 11, -50, 47, 17, -57, 6, 50, -63; /M: SY='D'; M= -19, -73, 72, -46, -71, -63, -55, -65, 11, 15, 13, 45, -69, 34, -56, 10, -5, -65, -85, -65; /M: SY='W'; M= 2, -77, -2, -3, -66, -8, -60, -65, 44, -16, 13, 2, 30, 16, 14, -13, -59, -18, 58, 12; /M: SY='N'; M= -58, -72, 22, -57, -62, 6, -57, -9, -13, -18, 48, 55, -71, 37, -60, -6, 1, 25, -76, 19; /M: SY='H'; M= -61, -79, -52, 49, -73, 25, 53, -6, 51, -71, -64, 8, 31, -49, -50, -58, -61, -21, 46, -63; /M: SY='N'; M= 9, 26, 3, -60, -68, -12, -62, 8, -9, -3, -57, 65, 30, -60, -64, -12, 22, -1, -84, -68; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 4 in 4 different sequences |
| Number of true positive hits | 4 in 4 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | NCOA4 HERC2-binding (HBD) |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
4 sequences
NCO4B_XENLA (Q5FWP7), NCOA4_DANRE (Q802X2), NCOA4_HUMAN (Q13772), NCOA4_MOUSE (Q5U4H9)» more
|
| PDB [Detailed view] |
1 PDB
pdb_00009l93 |