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ProRule PRU01434


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PURL: https://purl.expasy.org/prosite/rule/PRU01434
General rule information [?]

Accession PRU01434
Dates 06-FEB-2026 (Created)
12-FEB-2026 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS50813; GAF
Name GAF domain
Function GAF domains in general may regulate allosterically catalytic activities via the binding of ligands, such as nucleotides and small molecules. Given the diverse evolutionary and functional contexts within which GAF domains are found, it has been proposed that not all these domains possess identical functions.
Scope(s) Bacteria
Eukaryota
Archaea
Stenosarchaea group
Example(s) P32039;

Propagated annotation [?]

Comments [?]

case <Feature:PS50813:96-97=C-H> and <OC:Viridiplantae>
PTMContains one covalently linked phytochromobilin chromophore.
SIMILARITYBelongs to the phytochrome family.
end case
case <Feature:PS50813:101-103=H-P>
COFACTOR Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 1 heme group per monomer;

Keywords [?]

Heme
end case

Features [?]

From: PS50813
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="GAF #"
case <Feature:PS50813:96-97=C-H> and <OC:Viridiplantae>
BINDING 96 96 /ligand="phytochromobilin"
/ligand_id="ChEBI:CHEBI:189064"
/note="covalent"
else case <Feature:PS50813:96-97=C-H> and <OC:Cyanophyceae>
BINDING 96 96 /ligand="(2R,3E)-phycocyanobilin"
/ligand_id="ChEBI:CHEBI:85275"
/note="covalent"
end case
case <Feature:PS50813:101-103=H-P-P>
BINDING 101 101 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"
end case

Additional information [?]

Size range 42-260 amino acids
Related rules None
Fusion None
Repeats 1-3
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]