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ProRule PRU01435


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PURL: https://purl.expasy.org/prosite/rule/PRU01435
General rule information [?]

Accession PRU01435
Dates 18-FEB-2026 (Created)
18-FEB-2026 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS52089; HTH_NTRC
Name NtrC-type HTH DNA-binding domain
Function The NtrC-type HTH DNA-binding domain often binds to two high- affinity cooperative binding sites located ~100 bp upstream of the sigma(54)- binding site. The NtrC-type HTH DNA-binding domain consists of three well- defined alpha-helices: the dimerization helix, the first helix of the HTH, and the recognition helix, in keeping with general naming conventions for HTH proteins.
Scope(s) Bacteria
Example(s) P0A6R9;

Propagated annotation [?]

Keywords [?]

DNA-binding
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Features [?]

From: PS52089
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HTH NtrC-type #"
DNA_BIND 26 49 /note="H-T-H motif"

Additional information [?]

Size range 31-53 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]