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ProRule PRU01436


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PURL: https://purl.expasy.org/prosite/rule/PRU01436
General rule information [?]

Accession PRU01436
Dates 25-FEB-2026 (Created)
27-FEB-2026 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS52090; H_NOX
Name Heme-nitric oxide/oxygen binding (H-NOX) domain
Function Heme-nitric oxide/oxygen binding (H-NOX) domains bind gaseous ligands for signal transduction in organisms spanning prokaryotic and eukaryotic kingdoms.
Scope(s) Eukaryota
Metazoa
Example(s) P20595;

Propagated annotation [?]

Comments [?]

case <Feature:PS52090:104=H>
COFACTOR Name=heme; Xref=ChEBI:CHEBI:30413;

Keywords [?]

case <Feature:PS52090:104=H>
Heme
end case
case <FTGroup:1>
Zinc
Metal-binding
end case

Gene Ontology [?]

GO:0020037; Molecular function:heme binding
end case
case <FTGroup:1>
GO:0046872; Molecular function:metal ion binding
end case

Features [?]

From: PS52090
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="H-NOX #"
BINDING 104 104 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="proximal binding residue"		 H
BINDING 141 141 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 164 164 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [HQ] 1
BINDING 167 167 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 178 178 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1

Additional information [?]

Size range 109-211 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]