ProRule PRU01445
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PURL: https://purl.expasy.org/prosite/rule/PRU01445
General rule information
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| Accession | PRU01445 |
| Dates | 22-APR-2026 (Created)
22-APR-2026 (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52101; PPK2 |
Name | Polyphosphate kinase family-2 (PPK2) domain |
| Function | In nature, polyphosphate (polyP) is synthesized and degraded by polyphosphate kinases (PPKs) that catalyze the reversible transfer of the terminal phosphoryl residue from nucleoside 5'-triphosphates to polyP. Two large, structurally unrelated families of bacterial PPKs have been characterized so far: PPK1 enzymes that favor polyP synthesis and the PPK2 family that favors nucleotide phosphorylation. |
| Scope(s) |
Bacteria |
| Example(s) | Q9HYF1 (PK22_PSEAE); |
Propagated annotation
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Keywords
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Features
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| From: PS52101 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="PPK2 #" | |||||||||
| MOTIF | 51 | 57 | /note="Walker A #" | x(2)-[DE]-x(2)-G-K | ||||||||
| MOTIF | 108 | 110 | /note="Walker B #" | [DN]-R-[ST] | ||||||||
| REGION | 159 | 189 | /note="lid module #" | x(6)-R-x(12)-K-x(4)-D-x(6) | ||||||||
| ACT_SITE | 53 | 53 | D | |||||||||
| BINDING | 53 | 53 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#2" |
[DE] | ||||||||
| BINDING | 183 | 183 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#1" |
D | ||||||||
Additional information
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| Size range | 113-253 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [20] All [ 20 ]
- Retrieve set of proteins with 3D structure for this domain