ProRule PRU01451
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PURL: https://purl.expasy.org/prosite/rule/PRU01451
General rule information
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| Accession | PRU01451 |
| Dates | 29-MAY-2026 (Created)
29-MAY-2026 (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52107; FV_VP40 |
Name | Filovirus VP40 matrix protein |
| Function | The filovirus matrix protein, VP40, binds to and concentrates at the plasma membrane of infected cells, where it can interact with components of the nucleocapsid to promote envelopment, and where it drives formation of the filamentous virus particles. In addition, VP40 has been shown to regulate viral replication and transcription. |
| Scope(s) |
Viruses Filoviridae |
| Example(s) | P35260 (VP40_MABVM); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | AltName: Full=Matrix protein VP40; AltName: Full=Membrane-associated protein VP40; |
Comments
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| MISCELLANEOUS | Most abundant protein in the virion. |
| SIMILARITY | Belongs to the filoviridae matrix protein VP40 family. |
Keywords
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Gene Ontology
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| GO:0039660; Molecular function:structural constituent of virion |
| GO:0020002; Cellular component:host cell plasma membrane |
| GO:0039702; Biological process:viral budding via host ESCRT complex |
| GO:0055036; Cellular component:virion membrane |
| GO:0033645; Cellular component:host cell endomembrane system |
| GO:0044185; Cellular component:host cell late endosome membrane |
| GO:0052170; Biological process:symbiont-mediated suppression of host innate immune response |
Features
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| From: PS52107 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | 149 | /note="Filovirus VP40 N-terminal #" | |||||||||
| DOMAIN | 157 | to | /note="Filovirus VP40 C-terminal #" | |||||||||
| case <AnyFeature:PS52107:290-296=C-x*-C> | ||||||||||||
| DISULFID | 290 | 296 | disulf | |||||||||
| else case <AnyFeature:PS52107:287-290=C-x*-C> | ||||||||||||
| DISULFID | 287 | 290 | disulf | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 275-284 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.