ProRule PRU01453
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PURL: https://purl.expasy.org/prosite/rule/PRU01453
General rule information
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| Accession | PRU01453 |
| Dates | 11-JUN-2026 (Created)
16-JUN-2026 (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52109; FV_L_CT |
Name | Filovirus large (L) protein C-terminal (CTD) domain |
| Function | The filovirus L CTD, which is enriched in basic amino acids, plays a key role in RNA binding and in turn regulates the different MTase activities. It selectively contributes to the right positioning of RNA in the MTase catalytic site, thereby regulating the different MTase activities of the protein. Consequently, it participates in viral replication and escape of the host innate immunity. |
| Scope(s) |
Viruses Filoviridae |
| Example(s) | P35262 (L_MABVP); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=RNA-directed RNA polymerase L; Short=Protein L; |
Comments
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| SUBCELLULAR LOCATION | Host cytoplasm. Virion. |
Features
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| From: PS52109 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Filovirus L C-terminal #" | |||||||||
Additional information
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| Size range | 169-170 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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