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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU10115


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10115
General rule information [?]

Accession PRU10115
Dates 16-OCT-2006 (Created)
14-OCT-2024 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS01062; HMG_COA_LYASE
Name Hydroxymethylglutaryl-coenzyme A lyase active site
Function Undefined
Scope(s) Eukaryota
Bacteria
Example(s) P35914;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name AltName: Full=Hydroxymethylglutaryl-CoA lyase;
                 EC=4.1.3.4;

Comments [?]

CATALYTIC ACTIVITY Reaction=(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl- CoA; Xref=Rhea:RHEA:24404, ChEBI:CHEBI:13705, ChEBI:CHEBI:43074, ChEBI:CHEBI:57288; EC=4.1.3.4;

Features [?]

From: PS01062
Key From To Description Tag Condition FTGroup
ACT_SITE 8 8

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]