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ProRule PRU10127


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU10127
Accession PRU10127
Dates 16-OCT-2006 (Created)
14-MAY-2022 (Last updated, Version 10)
Data class Protein;
Predictors PROSITE; PS00171; TIM_1
PROSITE; PS51440; TIM_2
Name Triosephosphate isomerase (TIM) family
Function Triosephosphate isomerase (EC 5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate.
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) Q928I1 (TPIS1_LISIN); P34937 (TPIS_HORVU);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1> and <FTGroup:2>
Identifier TPIS
Protein name + RecName: Full=Triosephosphate isomerase;
                 Short=TIM;
                 EC=5.3.1.1;
AltName: Full=Triose-phosphate isomerase;
else case <FTGroup:1>
Protein name + RecName: EC=5.3.1.-;
end case
case <FTGroup:1> and <FTGroup:2>
Gene name Name=tpiA;

Comments [?]

CATALYTIC ACTIVITY Reaction=D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate; Xref=Rhea:RHEA:18585, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=5.3.1.1;
PATHWAYCarbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate from glycerone phosphate: step 1/1.
PATHWAYCarbohydrate biosynthesis; gluconeogenesis.
SUBUNITHomodimer.
SUBCELLULAR LOCATIONCytoplasm.
end case
case <FTGroup:1> and <FTGroup:2> and <OC:Viridiplantae>
MISCELLANEOUSIn plants, there are two types of TPIS, cytosolic and plastid.
end case
SIMILARITYBelongs to the triosephosphate isomerase family.

Keywords [?]

Isomerase
Gluconeogenesis
Glycolysis
Pentose shunt
Cytoplasm
end case

Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2>
GO:0004807; Molecular function:triose-phosphate isomerase activity
GO:0006096; Biological process:glycolytic process
GO:0006094; Biological process:gluconeogenesis
GO:0006098; Biological process:pentose-phosphate shunt
GO:0005737; Cellular component:cytoplasm

Features [?]

From: PS51440
Key From To Description Tag Condition FTGroup
ACT_SITE 91 91 /note="Electrophile" H 1
ACT_SITE 162 162 /note="Proton acceptor" E 1
case <FTGroup:1>
BINDING 7 7 /ligand="substrate" N 2
BINDING 9 9 /ligand="substrate" K 2
end case
From: PS00171
Key From To Description Tag Condition FTGroup
case not <AnyFeature:PS51440>
ACT_SITE 3 3 /note="Proton acceptor"
end case

Additional information [?]

Size range 200-290 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]