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annotation rule: PRU10127

General rule information [?]

Accession PRU10127
Dates 16-OCT-2006 (Created)
14-MAY-2022 (Last updated, Version 10)
Data class Protein
Predictors PROSITE; PS00171; TIM_1
Predictors PROSITE; PS51440; TIM_2
Name Triosephosphate isomerase (TIM) family
Function Triosephosphate isomerase (EC 5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate.

Propagated annotation [?]


Description [?]

case <FTGroup:1> and <FTGroup:2>
Identifier TPIS
+ RecName: Full=Triosephosphate isomerase; Short=TIM; EC 5.3.1.1; AltName: Full=Triose-phosphate isomerase;
else case <FTGroup:1>
+ RecName: EC 5.3.1.-;
end case

case <FTGroup:1> and <FTGroup:2>
Gene name tpiA

Comments [?]

Catalytic activity RHEA:18585: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
EC 5.3.1.1
Pathway Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Carbohydrate biosynthesis; gluconeogenesis.
Subunit Homodimer.
Subcellular location Cytoplasm.
end case

case <FTGroup:1> and <FTGroup:2> and <OC:Viridiplantae>
Miscellaneous In plants, there are two types of TPIS, cytosolic and plastid.
end case

Similarity Belongs to the triosephosphate isomerase family.

Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2>
GO:0004807; Molecular function: triose-phosphate isomerase activity.
GO:0006096; Biological process: glycolytic process.
GO:0006094; Biological process: gluconeogenesis.
GO:0006098; Biological process: pentose-phosphate shunt.
GO:0005737; Cellular component: cytoplasm.

Keywords [?]

Isomerase
Gluconeogenesis
Glycolysis
Pentose shunt
Cytoplasm
end case


Features [?]

From: PS51440
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     91     91       Electrophile     H   1
ACT_SITE     162     162       Proton acceptor     E   1
case <FTGroup:1>
BINDING     7     7       /ligand="substrate     N   2
BINDING     9     9       /ligand="substrate     K   2
end case

case not <AnyFeature:PS51440>
From: PS00171
ACT_SITE     3     3       Proton acceptor        
end case


Additional information [?]

Size range 200-290 amino acids
Related rules None
Repeats 1
Topology Undefined
Examples Q928I1 (TPIS1_LISIN); P34937 (TPIS_HORVU): [Recover all]
Scope
Eukaryota
Bacteria
Archaea

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]