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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU10138


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10138
General rule information [?]

Accession PRU10138
Dates 21-AUG-2009 (Created)
22-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS00014; ER_TARGET
Name Endoplasmic reticulum targeting sequence
Function Proteins that permanently reside in the lumen of the endoplasmic reticulum (ER) seem to be distinguished from newly synthesized secretory proteins by the presence of the C-terminal sequence Lys-Asp-Glu-Leu (KDEL).
Scope(s) Eukaryota
Viruses
Example(s) Q9Y2B0;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONEndoplasmic reticulum.

Keywords [?]

Endoplasmic reticulum

Gene Ontology [?]

GO:0005783; Cellular component:endoplasmic reticulum

Features [?]

From: PS00014
Key From To Description Tag Condition FTGroup
MOTIF from to /note="Prevents secretion from ER"

Additional information [?]

Size range 4 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]