ProRule PRU10138
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU10138 |
| Accession | PRU10138 |
| Dates | 21-AUG-2009 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS00014; ER_TARGET |
Name | Endoplasmic reticulum targeting sequence |
| Function | Proteins that permanently reside in the lumen of the endoplasmic reticulum (ER) seem to be distinguished from newly synthesized secretory proteins by the presence of the C-terminal sequence Lys-Asp-Glu-Leu (KDEL). |
| Scope(s) |
Eukaryota Viruses |
| Example(s) | Q9Y2B0 (CNPY2_HUMAN); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Endoplasmic reticulum. |
Keywords
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Gene Ontology
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| GO:0005783; Cellular component:endoplasmic reticulum |
Features
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| From: PS00014 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | from | to | /note="Prevents secretion from ER" | |||||||||
Additional information
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| Size range | 4 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [1] Eukaryota [388] Viruses [7] All [ 396 ]
- Retrieve set of proteins with 3D structure for this domain