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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU10145


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10145
General rule information [?]

Accession PRU10145
Dates 09-FEB-2024 (Created)
20-MAR-2025 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS01030; RNA_POL_M_15KD
Name RNA polymerases M / 15 Kd subunits
Function These proteins contain a probable zinc finger in their N-terminal region.
Scope(s) Eukaryota
Archaea
Example(s) Q07271;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

Keywords [?]

Metal-binding
Zinc
end case
Transcription
DNA-directed RNA polymerase
case <OC:Eukaryota>
Nucleus
end case

Gene Ontology [?]

GO:0003899; Molecular function:DNA-directed RNA polymerase activity
GO:0003676; Molecular function:nucleic acid binding
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS01030
Key From To Description Tag Condition FTGroup
BINDING 2 2 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 10 10 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1
BINDING 11 11 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 C 1

Additional information [?]

Size range 20-27 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]