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| annotation rule: PRU50000 |
General rule information
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| Accession | PRU50000 |
| Dates | 3-DEC-2007 (Created) 22-NOV-2019 (Last updated, Version 9) |
| Data class | Protein |
| Names | Large T antigen; LT; LT-AG |
Propagated annotation
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Description
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| Identifier | LT |
| RecName: Full=Large T antigen; Short=LT; Short=LT-AG; |
Comments
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| Function | Initiates DNA unwinding and replication via elaborate interactions with the viral origin of replication. |
| Subunit | Forms homohexamers in the presence of ATP. |
| Subcellular location | Nucleus. |
| Domain | The zinc finger region contributes to protein-protein interactions essential for the assembly of stable T-antigen hexamers at the origin of replication and hexamers are needed for subsequent alterations in the structure of origin DNA. |
Cross-references
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| PROSITE | PS50076; DNAJ_2; 1; trigger=PRU00286; |
| PS51287; T_AG_OBD; 1; trigger=PRU00620; | |
| PS51341; ZF_T_AG_D1; 1; trigger=PRU00671; | |
| PS51206; SF3_HELICASE_1; 1; trigger=PRU00551; |
Gene Ontology
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GO:0005634; Cellular component: nucleus.
Keywords
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Features
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Additional information
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| Size range | 580-790 amino acids |
| Related rules | None |
| Example | Q53R41 (FAKD1_HUMAN) |
| Scope | Eukaryota |
| Fusion | None |
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