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annotation rule: PRU50000 |
Accession | PRU50000 |
Dates | 3-DEC-2007 (Created) 22-NOV-2019 (Last updated, Version 9) |
Data class | Protein |
Names | Large T antigen; LT; LT-AG |
Identifier | LT |
RecName: Full=Large T antigen; Short=LT; Short=LT-AG; |
Function | Initiates DNA unwinding and replication via elaborate interactions with the viral origin of replication. |
Subunit | Forms homohexamers in the presence of ATP. |
Subcellular location | Nucleus. |
Domain | The zinc finger region contributes to protein-protein interactions essential for the assembly of stable T-antigen hexamers at the origin of replication and hexamers are needed for subsequent alterations in the structure of origin DNA. |
PROSITE | PS50076; DNAJ_2; 1; trigger=PRU00286; |
PS51287; T_AG_OBD; 1; trigger=PRU00620; | |
PS51341; ZF_T_AG_D1; 1; trigger=PRU00671; | |
PS51206; SF3_HELICASE_1; 1; trigger=PRU00551; |
Size range | 580-790 amino acids |
Related rules | None |
Example | Q53R41 (FAKD1_HUMAN) |
Scope | Eukaryota |
Fusion | None |