We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

ProRule PRU50000

View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU50000

General rule information [?]

Accession	PRU50000
Dates	03-DEC-2007 (Created) 22-NOV-2019 (Last updated, Version 10)
Data class	Protein;
Predictors	Metamotif; -; Nter~5,15~PS50076~15,220~PS51287~0,15~PS51341~35,50~PS51206~65,150~Cter
Name	Large T antigen
Function	None
Scope(s)	Eukaryota
Example(s)	Q53R41;

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LT
Protein name	RecName: Full=Large T antigen; Short=LT; Short=LT-AG;

Comments [?]

FUNCTION	Initiates DNA unwinding and replication via elaborate interactions with the viral origin of replication.
SUBUNIT	Forms homohexamers in the presence of ATP.
SUBCELLULAR LOCATION	Nucleus.
DOMAIN	The zinc finger region contributes to protein-protein interactions essential for the assembly of stable T-antigen hexamers at the origin of replication and hexamers are needed for subsequent alterations in the structure of origin DNA.

Keywords [?]

Early protein

Nucleus

Gene Ontology [?]

GO:0005634; Cellular component:nucleus

Cross-references [?]

PROSITE	PS50076; DNAJ_2; 1;
PROSITE	PS51287; T_AG_OBD; 1;
PROSITE	PS51341; ZF_T_AG_D1; 1;
PROSITE	PS51206; SF3_HELICASE_1; 1;

Features [?]

From: any

Key

From

Description

Tag

Condition

FTGroup

CHAIN

from

/note="Large T antigen"

Additional information [?]

Size range	580-790 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Repeats	None
Topology	None

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