ProRule PRU50000
General rule information
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| Accession | PRU50000 |
| Dates | 3-DEC-2007 (Created)
22-NOV-2019 (Last updated, Version 9) |
| Data class | Protein; |
| Predictors |
Metamotif; -; Nter~5,15~PS50076~15,220~PS51287~0,15~PS51341~35,50~PS51206~65,150~Cter |
Name | Large T antigen |
| Function | None |
| Scope(s) |
Eukaryota |
| Example(s) | Q53R41 (FAKD1_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LT |
| Protein name | RecName: Full=Large T antigen; Short=LT; Short=LT-AG; |
Comments
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| FUNCTION | Initiates DNA unwinding and replication via elaborate interactions with the viral origin of replication. |
| SUBUNIT | Forms homohexamers in the presence of ATP. |
| SUBCELLULAR LOCATION | Nucleus. |
| DOMAIN | The zinc finger region contributes to protein-protein interactions essential for the assembly of stable T-antigen hexamers at the origin of replication and hexamers are needed for subsequent alterations in the structure of origin DNA. |
Keywords
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Gene Ontology
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| GO:0005634; Cellular component:nucleus |
Cross-references
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| PROSITE | PS50076; DNAJ_2; 1; |
| PROSITE | PS51287; T_AG_OBD; 1; |
| PROSITE | PS51341; ZF_T_AG_D1; 1; |
| PROSITE | PS51206; SF3_HELICASE_1; 1; |
Features
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| From: any | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| CHAIN | from | to | /note="Large T antigen" | |||||||||
Additional information
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| Size range | 580-790 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Repeats | None |
| Topology | None |
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