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annotation rule: PRU50000

General rule information [?]

Accession PRU50000
Dates 3-DEC-2007 (Created)
22-NOV-2019 (Last updated, Version 9)
Data class Protein
Predictors Metamotif; -; Nter~5,15~PS50076~15,220~PS51287~0,15~PS51341~35,50~PS51206~65,150~Cter
Names Large T antigen; LT; LT-AG

Propagated annotation [?]

Description [?]

Identifier LT
RecName: Full=Large T antigen; Short=LT; Short=LT-AG;

Comments [?]

Function Initiates DNA unwinding and replication via elaborate interactions with the viral origin of replication.
Subunit Forms homohexamers in the presence of ATP.
Subcellular location Nucleus.
Domain The zinc finger region contributes to protein-protein interactions essential for the assembly of stable T-antigen hexamers at the origin of replication and hexamers are needed for subsequent alterations in the structure of origin DNA.

Cross-references [?]

PROSITE PS50076; DNAJ_2; 1; trigger=PRU00286;
PS51287; T_AG_OBD; 1; trigger=PRU00620;
PS51341; ZF_T_AG_D1; 1; trigger=PRU00671;
PS51206; SF3_HELICASE_1; 1; trigger=PRU00551;

Gene Ontology [?]

GO:0005634; Cellular component: nucleus.

Keywords [?]

Features [?]

From: any
Key     From     To       Description   Tag   Condition   FTGroup
CHAIN     from     to       Large T antigen        

Additional information [?]

Size range 580-790 amino acids
Related rules None
Example Q53R41 (FAKD1_HUMAN)
Fusion None


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