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ProRule PRU00107


General rule information [?]

Accession PRU00107
Dates 12-DEC-2003 (Created)
20-NOV-2019 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS50109; HIS_KIN
Name Histidine kinase core domain
Function Autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to a phosphoacceptor.
Scope(s) Eukaryota
Bacteria
Archaea
Viruses
Plastid
Mitochondrion
Example(s) P59963 (MTRB_MYCBO);

Propagated annotation [?]

Keywords [?]

Transferase
Kinase
case <FT:2>
Phosphoprotein
end case

Gene Ontology [?]

GO:0016740; Molecular function:transferase activity
GO:0016301; Molecular function:kinase activity

Features [?]

From: PS50109
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Histidine kinase #"
MOD_RES 4 4 /note="Phosphohistidine; by autocatalysis" H

Additional information [?]

Size range 157-356 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic
Comments Mitochondrial pyruvate dehydrogenase kinases (PDKs) (EC 2.7.1.99) contain an histidine kinase domain which possess a serine/threonine kinase activity.

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]