ProRule PRU00350
General rule information
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| Accession | PRU00350 |
| Dates | 26-JUL-2004 (Created)
21-NOV-2019 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50958; SMB_2 |
Name | Somatomedin B (SMB) domain |
| Function | The SMB domain of vitronectin has been demonstrated to interact with both the urokinase receptor and the plasminogen activator inhibitor-1 (PAI-1) and the conserved cysteines of the NPP1 somatomedin B-like domain have been shown to mediate homodimerization. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q9GZM7 (TINAL_HUMAN); |
Propagated annotation
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Keywords
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| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Cross-references
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| PROSITE | PS00524; SMB_1; 1; |
Features
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| From: PS50958 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="SMB #" | |||||||||
| DISULFID | 5 | 9 | /note="Alternate" | disulf | C-x*-C | |||||||
| DISULFID | 5 | 21 | /note="Alternate" | disulf | C-x*-C | |||||||
| DISULFID | 9 | 39 | /note="Alternate" | disulf | C-x*-C | |||||||
| DISULFID | 19 | 21 | /note="Alternate" | disulf | C-x*-C | |||||||
| DISULFID | 19 | 32 | /note="Alternate" | disulf | C-x*-C | |||||||
| DISULFID | 25 | 31 | disulf | C-x*-C | ||||||||
| DISULFID | 32 | 39 | /note="Alternate" | disulf | C-x*-C | |||||||
Additional information
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| Size range | 35-55 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 2 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [38] All [ 38 ]
- Retrieve set of proteins with 3D structure for this domain