ProRule PRU00399
General rule information
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| Accession | PRU00399 |
| Dates | 14-FEB-2005 (Created)
19-NOV-2022 (Last updated, Version 11) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51062; RUNT |
Name | Runt domain |
| Function | The Runt domain confers DNA binding ability to the consensus core PyGPyGGT and mediates the interaction of mammalian RUNX proteins with the beta-subunit, designated core-binding factor beta (CBFbeta), which increases the DNA binding affinity of the heterodimer. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q01196 (RUNX1_HUMAN); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
Keywords
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| case <FTGroup:1> or <FTGroup:2> | |
| Chloride | |
| end case | |
| DNA-binding | |
| Nucleus | |
| Transcription | |
| Transcription regulation | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0005634; Cellular component:nucleus |
| GO:0006355; Biological process:regulation of DNA-templated transcription |
| GO:0006351; Biological process:DNA-templated transcription |
Features
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| From: PS51062 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Runt #" | |||||||||
| REGION | 31 | 35 | /note="Interaction with DNA" | |||||||||
| REGION | 86 | 94 | /note="Interaction with DNA" | |||||||||
| REGION | 119 | 128 | /note="Interaction with DNA" | |||||||||
| BINDING | 63 | 63 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1" |
N | 1 | |||||||
| BINDING | 67 | 67 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1" |
E | 1 | |||||||
| BINDING | 90 | 90 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#2" |
R | 2 | |||||||
| BINDING | 121 | 121 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#2" |
V | 2 | |||||||
Additional information
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| Size range | 125-135 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [14] All [ 14 ]
- Retrieve set of proteins with 3D structure for this domain