ProRule PRU00660
General rule information
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| Accession | PRU00660 |
| Dates | 21-APR-2009 (Created)
11-JAN-2021 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51330; DHFR_2 |
Name | Dihydrofolate reductase (DHFR) domain |
| Function | Dihydrofolate reductases (DHFRs) (EC 1.5.1.3) are ubiquitous enzymes which catalyze the NADPH-linked reduction of 7,8-dihydrofolate to 5,6,7,8- tetrahydrofolate. |
| Scope(s) |
Bacteria Eukaryota Viruses Archaea |
| Example(s) | Q5V3R2 (DYR1_HALMA); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=1.5.1.3; |
Comments
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| CATALYTIC ACTIVITY | Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.3; |
Keywords
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Gene Ontology
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| GO:0016491; Molecular function:oxidoreductase activity |
| GO:0004146; Molecular function:dihydrofolate reductase activity |
| GO:0050661; Molecular function:NADP binding |
Cross-references
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| PROSITE | PS00075; DHFR_1; 1; |
Features
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| From: PS51330 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="DHFR #" | |||||||||
Additional information
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| Size range | 145-257 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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