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ProRule PRU01053


General rule information [?]

Accession PRU01053
Dates 11-MAY-2020 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS51716; G_IRG
Name IRG-type guanine nucleotide-binding (G) domain
Function The p47 or immunity-related GTPases (IRG) are at least as old as the vertebrates. The IRG proteins are an essential resistance system in the mouse for immunity against pathogens that enter the cell via a vacuole. Despite its importance for the mouse, the IRG resistance system is absent from humans because it has been lost during the divergent evolution of the primates. The IRG proteins appear to be accompanied phylogenetically by homologous proteins, named 'quasi IRG' (IRGQ) proteins, that probably lack nucleotide binding or hydrolysis function, and that may form regulatory heterodimers with functional IRG proteins.
Scope(s) Eukaryota
Eutheria
Example(s) Q6AYC2 (IRGM_RAT);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

Keywords [?]

GTP-binding
Hydrolase
Nucleotide-binding
end case

Gene Ontology [?]

case <Feature:PS51716:9-16=G-x(4)-G-[KM]-S> and <Feature:PS51716:59-62=D-x(2)-G> and <Feature:PS51716:116-119=[NT]-x-x-D>
GO:0005525; Molecular function:GTP binding

Features [?]

From: PS51716
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="IRG-type G #"

Additional information [?]

Size range 140-237 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]